Tarlige tablets 5 mg for peripheral neuropathic pain (mirogabalin besilate)

General information on Japanese Tarlige tablets 5 mg for peripheral neuropathic pain (mirogabalin besilate)

Package details: 100 tablets

Manufacturer: Daiichi Sankyo Co., Ltd., Japan

Active ingredient: mirogabalin besilate (chemical formula C12H19NO2C6H6O3S)

Medical effect: Tarlige tablets are effective for the treatment of peripheral neuropathic pain.

Contraindications and precautions: do not use for pregnant and breastfeeding women. Do not use for patients with renal dysfunction.

If an allergic reaction occurs, stop taking the medicine and consult with your doctor. If you’re taking any other medication, please consult with your doctor before use.

1. As this medicine may cause dizziness or somnolence, the patient should avoid operating in potentially hazardous activities such as driving a car.
2. Elderly patients should be aware of falling and fracture.
3. The patient should consult with the doctor in charge if the signs of blurred vision or double vision appear while taking this medication.
4. If the patient’s weight is increasing with no significant reason, consult with your doctor.

Dosage and administration of Tarlige tablets 5 mg from Japan for peripheral neuropathic pain (mirogabalin besilate)

For adults: start with 1 tablet (5 mg of mirogabalin) at a time, 2 times a day, as an initial dosage. Then gradually increase the dosage by 1 tablet (5 mg) at a time and continue to take increased dose at intervals of one week or more, and eventually take 3 tablets (15 mg) at a time, 2 times a day. The consulting doctor may adjust the dosage according to the age or symptoms to 2 tablets (10 mg) at a time, 2 times a day.

How effective are Tarlige tablets 5 mg from Japan for peripheral neuropathic pain (mirogabalin besilate)?

Tarlige tablets contain mirogabalin besilate, a new medicine of gabapentinoid class, the same as gabapentin and pregabalin. It works by a2delta-1 subunit of voltage-gated calcium (Ca2+) channels (both 1 and 2), but its analgesia is more sustained and the potency is significantly higher than pregabalin and other gabapentinoids.

Who should take Tarlige tablets 5 mg from Japan?

Tarlige tablets are effective for the treatment of peripheral neuropathic pain and decreasing its impact on sleep, mood and functionality. Studies showed that mirogabalin has a superior adverse events profile when compared to other gabapentinoids due to a rapid dissociation, being generally safe and well-tolerated (A. Vinik, J, Rosenstock et al. “Efficacy and Safety of Mirogabalin (DS-5565) for the Treatment of Diabetic Peripheral Neuropathic Pain: A Randomized, Double-Blind, Placebo- and Active Comparator–Controlled, Adaptive Proof-of-Concept Phase 2 Study”. Diabetes Care, 2014, December; 37(12): 3253-3261).