Pravastatin Na tablets 5 mg for hyperlipidemia and hypercholesterolemia (statin, Pravachol)

General information on Japanese Pravastatin Na tablets 5 mg for hyperlipidemia and hypercholesterolemia (statin, Pravachol)

Package details: 100 tablets

Manufacturer: Sawai Pharmaceutical Co. Ltd. / Nipro Corporation / Mitsubishi Tanabe Pharma Co., Ltd., Japan

Active ingredients: pravastatin sodium (chemical formula C23H35NaO7)

Medical effect: Pravastatin Na tablets are effective for the treatment of hyperlipidemia and familial hypercholesterolemia.

Contraindications and precautions: do not use for pregnant, possibly pregnant or breastfeeding women. Do not use for patients with renal disorder.

The patient should strictly follow the instructions on dietary and exercise therapy.

If an allergic reaction occurs, stop taking the medicine and consult with your doctor. If you’re taking any other medication or receiving any other treatment, you have to consult with your doctor before use.

Dosage and administration

For adults, take 2 tablets (10 mg of the active ingredient), once a day or in 2 divided doses a day. The doctor in charge may adjust the dose according to the patient’s age or symptoms. If the symptoms are severe, the dosage may be increased up to 4 tablets (20 mg) a day.

How effective are Pravastatin Na tablets 5 mg from Japan for hyperlipidemia and hypercholesterolemia (statin, Pravachol)?

Pravastatin is a lipoprotein-lowering medicine of statin class. It works by inhibiting a cholesterol-producing enzyme and inhibiting the synthesis of very-low-density lipoproteins. Unlike almost all other statins, Pravastatin is cleared by the kidneys, not by the liver, thus it has less interactions with other medicines using the hepatic pathway and can be used for patients with the liver dysfunction, thought the monitoring of the consulting doctor is required.

Who should use Pravastatin Na tablets 5 mg from Japan?

Pravastatin tablets are prescribed for the following purposes:

• treatment of the hyperlipidemia and familial hypercholesteremia, which is the main indication for use of Pravastatin Na tablets,
• decrease of LDL cholesterol and increase of HDL cholesterol level,
• decrease of triglycerides level in blood.

Study that lasted for 16 years and involved more than 7000 patients, showed that pravastatin decreases the risk of death from cardiovascular events in a long-term perspective (W. E. Hague, J. Simes et al. “Long-Term Effectiveness and Safety of Pravastatin in Patients With Coronary Heart Disease”. Circulation. 2016, 133: 1851–1860).