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John

Great product, original Japanese Lactis EL027826792JP
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Mike

Good effect. I shall order again. Original made-in-japan package as promised EG401137451JP
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May

Real Japanese laennec. Thank you! I shall order again. EJ377189782JP
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Bob

Great effect! Got my hair back in 3 months. EG401137588JP
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Nike

Lost 3 kilos since started to drink it last month. Great for fitness EG299855913JP
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Any

Bought it for my son. Good effect and great service. EG299855961JP
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Nya

Original touchi, fast delivery and good price. Thank you. EG401137156JP
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Sam

Good medicine. Think it really helps me to fight cancer. EL025661542JP
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Reviews

John

3 times cheaper than in our country! And great effect for knees EJ365886698JP
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Reviews

Mike

Great thing to support diet. Lost 4 kilos for 6 weeks. Shall order more EJ365886675JP
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Home Japanese Supplements Anemia
Evrenzo tablets 50 mg for renal anemia (roxadustat)
Evrenzo tablets 50 mg for renal anemia (roxadustat)
Evrenzo tablets 50 mg for renal anemia (roxadustat)
Product Code Evrenzo
Availability 12
Price USD 598.00
Qty
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Evrenzo tablets 50 mg for renal anemia (roxadustat)

Product Code : Evrenzo

Availability : 12

USD 598.00

Buy now

General information on Japanese Evrenzo tablets 50 mg for renal anemia (roxadustat)

Package details: 30 tablets

Manufacturer: Astellas Pharma Inc., Japan

Active ingredient: roxadustat (chemical formula C19H16N2O5)

Medical effect: Evrenzo tablets are effective for the treatment of anemia attributable to renal diseases.

Contraindications and precautions: do not use for the following categories of patients:

  • patients with a history of cerebral infarction, myocardial infarction or pulmonary embolism,
  • patients with hypertension,
  • pregnant or possibly pregnant women,
  • breastfeeding women.

If an allergic reaction occurs, stop taking the medicine and consult with your doctor. If you’re taking any other medication or receiving any other treatment, you have to consult with your doctor before use.

Serum concentrations of hemoglobin should be checked periodically while taking this medicine. Also, the patient needs to take iron to get an adequate efficacy.

In order to avoid a possibility of pregnancy, female patients should use adequate contraception while taking this medicine and for a certain period of time after the last dose of this medicine.

As the lacteal transfer has been reported in animal experiments, female patients should avoid breastfeeding from the start to 28 days after the last dose of this medicine.

Dosage and administration of Evrenzo tablets 50 mg from Japan for renal anemia (roxadustat)

For patients untreated by erythropoiesis stimulating agent: for adults, start with 1 tablet (50 mg of roxadustat) at a time, 3 times a week, at intervals of 2 to 3 days (e.g. on Monday/Wednesday/Friday or on Tuesday/Thursday/Saturday). Thereafter, the dosage may be adjusted by doctor in charge according to the condition of the patient. The maximum single dose is 3.0 mg/kg.

For patients switching from erythropoiesis stimulating agent: for adults, start with either 70 mg or 100 mg of the active ingredient at a time, 3 times a week, at intervals of 2 to 3 days (e.g. on Monday/Wednesday/Friday or on Tuesday/Thursday/Saturday). Thereafter, the dosage may be adjusted by the doctor in charge according to the condition of the patient. The maximum single dose is 3.0 mg/kg.

Please note that this medicine contains 50 mg of the active ingredient in a tablet.

How effective are Evrenzo tablets 50 mg from Japan for renal anemia (roxadustat)?

Evrenzo tablets contain Roxadustat, a new inhibitor of HIF (hypoxia inducible factor), transcription factor that responds to decreases in available oxygen in the cellular environment. It works by activating HIF pathways and degrading HIF, by this, increasing endogenous production of erythropoietin, a glycoprotein cytokine secreted mainly by the kidney in response to cellular hypoxia. As the result, Evrenzo tablets stimulate red blood cell production (erythropoiesis) and production of hemoglobin, increase the increase the number of red blood cells and improve the symptoms of renal anemia.

Who should take Evrenzo tablets 50 mg from Japan?

At first, roxadustat was approved for using in patients undergoing dialysis, but since 2020 it was also approved in Japan for patients not receiving dialysis. Multiple studies showed that roxadustat leads to a numerically greater mean change in hemoglobin level, increases the transferrin level, decreases total cholesterol and low-density lipoprotein cholesterol level (T. Akizawa, M. Ueno et al. “Oral roxadustat three times weekly in ESA-naive and ESA-converted patients with anemia of chronic kidney disease on hemodialysis”. Therapeutic apheresis and dialysis, 2020, December, 24(6): 628-641). That’s why Evrenzo tablets are effective for the treatment of anemia attributable to renal diseases.

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Shipping to USA, EU, Asia, Oceania and South America in June

Notification from 1st June 2021 - Regarding shipping in Pandemic and Japan Post Stop Act. Dear Customers!   WE CAN SHIP to USA, EU, UAE, Australia, New Zealand, Canada, Hong-Kong, China, Korea, Vietnam, Mexico and all other countries!   Japan Post imposed restrictions on shipping to most of other coutnries. Situation changes eevry day, you can find latest news here - https://www.post.japanpost.jp/int/information/index_en.html Please use search on page to find your country.   IF JAPAN POST DOES NOT SHIP OR SHIPS BY SURFACE MAIL ONLY WE CAN SHIP BY COURIER.   For shiping by Japan Post check this link with full list of countries https://www.post.japanpost.jp/int/information/overview_en.html For shipping by Сourier check table below or contact us as situation changes every day.   SEE TABLE BELOW. SEE COMMENTS BELOW TABLE IF YOU CAN NOT FIND YOUR COUNTRY -- CONTACT US! W CAN SHIP. Shipping type Economy Mail ** Express Service Methods: * SURFACE AIRMAIL Courier05 *** EMS  Argentina NO YES YES YES Armenia YES  YES YES NO Australia YES  YES YES NO Austria YES  YES YES YES Azerbaijan YES  YES YES NO Belarus YES  YES YES NO Belgium YES  YES YES YES Brazil YES NO YES NO Bulgaria YES  YES YES YES Canada YES  YES YES NO Chile NO YES YES YES China YES  YES YES YES Colombia NO YES YES YES Congo YES NO YES NO Costa Rica YES NO YES NO Croatia YES  YES YES YES Cyprus NO YES YES YES Czech YES  YES YES YES Denmark YES  YES YES YES Ecuador NO NO YES NO Egypt YES YES YES NO Estonia YES  YES YES YES Finland YES  YES YES YES France YES  YES YES YES Georgia YES NO YES NO Germany YES  YES YES YES Great Britain YES  YES YES YES Greece YES  NO YES NO Hungary YES  YES YES YES India YES  NO YES NO Indonesia YES  YES YES YES Iran / Iraq NO YES  NO YES Ireland YES YES YES YES Israel YES NO YES NO Italy YES  YES YES YES Kazakhstan YES  NO NO NO Kenya NO YES YES YES Laos YES NO YES NO Latvia YES  YES YES YES Liechtenstein YES  YES YES YES Lithuania YES  YES YES YES Luxemurbg YES  YES YES YES Malaysia YES  NO YES NO Mexico YES  YES YES YES Moldova YES NO YES NO Mongolia NO NO YES NO New Zealand YES  YES YES YES Norway YES  YES YES YES Pakistan NO YES YES YES Panama NO NO YES NO Peru YES NO YES NO Poland YES  YES YES YES Portugal YES  YES YES YES Romania YES  NO YES NO Russia YES NO NO (ASK US) NO Saudi Arabia YES NO YES NO Serbia YES  YES YES NO Slovakia YES  YES YES NO Spain YES  YES YES YES Sri Lanka YES  YES YES YES Sweden YES  YES YES YES Switzerland YES  YES YES YES Tajikistan YES NO YES NO Turkey YES  YES YES YES UAE (Dubai) YES  NO YES NO Ukraine YES YES NO YES USA YES  YES* YES NO Uzbekistan YES NO YES NO Vietnam YES  YES YES YES           * We select appropriate available method. If you need specific method contact us. ** Economy mail is shipped by Air if airmail is available, if not we ship by Surface mail. There are restrictions applied by Japan Post. *** Courier-05, shipping for parcels with tablets up to 5 boxes (most cases), vials 10-20 pcs drops up to 0,5 kg in weight. Can ship to specific regions/cities, please check before order. IF YOU DO NOT SEE COUNTRY ON LIST, CONTACT US!   USA: - EXPRESS SERVICE. We ship by express, Delivery takes 8-12 days.  - AIRMAIL MAIL. If you prefer economy mail, we ship by standard airmail, takes 2-4 weeks, no tracking, only local number in Japan, Rate starts at 29 usd, free shipping for orders above 400 usd and 2 kg. If you can wait use this method.   EU - EUROPE We ship as usual to all countries besides Greece, Romania, Moldova and Russia.  For Romania, Greece and Moldova: We ship using express service to all other countries in EU at the moment. Or by surface mail.   ASIA - SINGAPORE, HONG KOG, KOREA, TAIWAN, THAILAND, VIETNAM, MALAYSIA, PHILIPPINES. We ship as usual (with possible delays) to these countries   SHIPPING TO CHINA. We ship as usual by EMS or Airmail.    SHIPPING TO INDIA. - WE CAN SHIP BY COURIER. We can ship by express method almost everything. Delivery takes 8-14 days. USE EXPRESS METHOD. - WE SHIP BY SURFACE MAIL. This takes 6-8 weeks or more, we offer tracking, Rate starts at 19 usd, free shipping for orders above 400 usd. If you can wait use this method. We can only ship vials and glass using surface mail.   OCEANIA - AUSTRALIA. NEW ZEALAND To Australia: - EXPRESS SERVICE. We ship by express, Delivery takes 8-12 days.  - AIRMAIL MAIL. If you prefer economy mail, we ship by surface mail, takes 2-4 weeks, no tracking, only local number in Japan, Rate starts at 29 usd, free shipping for orders above 400 usd and 2 kg. If you can wait use this method. TO NEW ZEALAND - WE SHIP AS USUAL    BRAZIL - WE CAN SHIP BY COURIER. We can ship by express method almost everything. Delivery takes 8-14 days. USE EXPRESS METHOD. - WE SHIP BY SURFACE MAIL. This takes 10-15 weeks or more, we offer tracking, Rate starts at 19 usd, free shipping for orders above 400 usd. If you can wait use this method. We can only ship vials and glass using surface mail.   CANADA - EXPRESS SERVICE. We ship by express, Delivery takes 8-12 days.  - AIRMAIL MAIL. If you prefer economy mail, we ship by surface mail, takes 2-4 weeks, no tracking, only local number in Japan, Rate starts at 29 usd, free shipping for orders above 400 usd and 2 kg. If you can wait use this method.   UKRAINE, KAZAKHSTAN. RUSSIA. - WE CAN SHIP TO UKRANE and BELARUS as usual by  AIRMAIL WITH POSSIBLE DELAYS. EMS and courier is available for Ukraine.  - Only surface mail is allowed for Russia  and Kazakhstan due to strict customs control for all other methods. We can ship by Fedex at your responsibility.
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Reviews

John

Great product, original Japanese Lactis EL027826792JP
more ▶

Reviews

Mike

Good effect. I shall order again. Original made-in-japan package as promised EG401137451JP
more ▶

Reviews

May

Real Japanese laennec. Thank you! I shall order again. EJ377189782JP
more ▶

Reviews

Bob

Great effect! Got my hair back in 3 months. EG401137588JP
more ▶

Reviews

Nike

Lost 3 kilos since started to drink it last month. Great for fitness EG299855913JP
more ▶

Reviews

Any

Bought it for my son. Good effect and great service. EG299855961JP
more ▶

Reviews

Nya

Original touchi, fast delivery and good price. Thank you. EG401137156JP
more ▶

Reviews

Sam

Good medicine. Think it really helps me to fight cancer. EL025661542JP
more ▶

Reviews

John

3 times cheaper than in our country! And great effect for knees EJ365886698JP
more ▶

Reviews

Mike

Great thing to support diet. Lost 4 kilos for 6 weeks. Shall order more EJ365886675JP
more ▶