Twymeeg tablets 500 mg for type 2 diabetes (imeglimin hydrochloride)

General information on Japanese Twymeeg tablets 500 mg for type 2 diabetes (imeglimin hydrochloride)

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Package details: 100 tablets

Manufacturer: Sumitomo Dainippon Pharma Co., Ltd., Japan

Active ingredients: imeglimin hydrochloride (chemical formula C6H14ClN5)

Medical effect: Twymeeg tablets are effective for the treatment of type 2 diabetes.

Contraindications and precautions: use with caution in elderly patients. Do not use for the following categories of patients:

• pregnant or breastfeeding women,
• children,
• patients with pituitary dysfunction or adrenal dysfunction,
• patients with malnutrition, starvation, irregular dietary intake, lack of dietary intake or weakness,
• patients regularly taking intense muscle exercise,
• patients prone to excessive alcohol intake
• patients with renal or liver dysfunction (especially patients with eGFR less than 45 mL/min/1.73 m2 and patients on dialysis).

If an allergic reaction occurs, stop taking the medicine and consult with your doctor. If you’re taking any other medication or receiving any other treatment, you have to consult with your doctor before use.

Dosage and administration of Twymeeg tablets 500 mg from Japan for type 2 diabetes (imeglimin hydrochloride)

For adults, take 2 tablets (1000 mg of the active ingredient) 2 times a day, in the morning and in the evening.

How effective are Twymeeg tablets 500 mg from Japan for type 2 diabetes (imeglimin hydrochloride)?

Twymeeg tablets are a new oral anti-diabetic medicine. Its active ingredient is imeglimin, an oxidative phosphorylation blocker, the first in its class. It works by inhibiting hepatic gluconeogenesis, increasing muscle glucose uptake, and restoring normal insulin secretion. The dual mechanism of action of imeglimin has the potential to prevent endothelial and diastolic dysfunction, which could provide protective effects on micro- and macrovascular defects induced by diabetes.

Who should use Twymeeg tablets 500 mg from Japan?

Twymeeg tablets are effective for the treatment of type 2 diabetes. Imeglimin has been studied in 28 clinical trials with more than 1800 patients. Studies showed that it has the potential to slow disease progression, to provide therapeutic options to patients who no longer respond to current treatments, to complement existing treatments and to impact complications of diabetes, such as cardiac dysfunction and nephropathy (S. Hallakou-Bozec, G. Vial et al. “Mechanism of action of Imeglimin: A novel therapeutic agent for type 2 diabetes”. Diabetes, Obesity and Metabolism, 2021 March; 23(3): 664-673).