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Parkinson's Disease

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John

Great product, original Japanese Lactis EL027826792JP
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Mike

Good effect. I shall order again. Original made-in-japan package as promised EG401137451JP
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May

Real Japanese laennec. Thank you! I shall order again. EJ377189782JP
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Bob

Great effect! Got my hair back in 3 months. EG401137588JP
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Reviews

Nike

Lost 3 kilos since started to drink it last month. Great for fitness EG299855913JP
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Any

Bought it for my son. Good effect and great service. EG299855961JP
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Nya

Original touchi, fast delivery and good price. Thank you. EG401137156JP
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Sam

Good medicine. Think it really helps me to fight cancer. EL025661542JP
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Reviews

John

3 times cheaper than in our country! And great effect for knees EJ365886698JP
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Reviews

Mike

Great thing to support diet. Lost 4 kilos for 6 weeks. Shall order more EJ365886675JP
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Home Japanese Medicines Parkinson's Disease
Trerief tablets 50 mg for Parkinson’s disease (zonisamide)
Trerief tablets 50 mg for Parkinson’s disease (zonisamide)
Product Code Trerief
Availability 12
Price USD 1,090.00
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Trerief tablets 50 mg for Parkinson’s disease (zonisamide)

Product Code : Trerief

Availability : 12

USD 1,090.00

Buy now

General information on Japanese Trerief tablets 50 mg for Parkinson’s disease (zonisamide)

Package details: 30 tablets

Manufacturer: Sumitomo Dainippon Pharma Co.,Ltd., Japan

Active ingredient: zonisamide (chemical formula C8H8N2O3S)

Medical effect: Trerief tablets are effective for the treatment of Parkinson’s disease.

Contraindications and precautions: do not use in pregnant and breastfeeding women.

As this medicine may cause drowsiness or lack of concentration, avoid working with dangerous mechanisms or driving a car while taking this medicine. If an allergic reaction occurs, stop taking the medicine and consult with your doctor. If you’re taking any other medication, please consult with your doctor before use.

Dosage and administration of Trerief tablets 50 mg from Japan for Parkinson’s disease (zonisamide)

For adults, take 0.5 tablet (25 mg of the active ingredient) once a day, concomitantly with levodopa-containing products. For improvement of circadian change of symptoms in Parkinson's disease, take 1 tablet (50 mg) once a day, concomitantly with levodopa-containing products.

The medicine can be taken with or without water. If you use it without water, moisten the tablet with saliva on the tongue and crush it lightly with the tongue, then swallow it with saliva.

How effective are Japanese Trerief tablets 50 mg for Parkinson’s disease (zonisamide)?

Trerief tablets contain zonisamide, a sulfonamide anticonvulsant and a carbonic anhydrase inhibitor. They provide the following effects:

  1. elevate the dopamine level,
  2. enhance and prolong antiparkinsonian effect of levodopa,
  3. improves motor symptoms,
  4. improve the circadian change of symptoms (wearing-off phenomenon).

Who should take Trerief tablets 50 mg from Japan?

Zonisamide was primarily used as an anticonvulsant for patient with epilepsy. Later, this medicine was found to improve the symptoms of Parkinson’s disease in patients who had both epilepsy and Parkinson’s disease. Currently, Trerief tablets have been studied in clinical trials and approved in Japan for the treatment of the motor symptoms of Parkinson's disease, as an adjunct to levodopa. Studies showed that zonisamide allows to decrease the amount of levodopa, induce quinone formation and protection against mitochondrial impairment, increase astroglial cysteine transport, inhibit the microglial activation and monoamine oxidase-B (MAO-B), increase dopamine release and block the calcium channels (N. D. Grover, R. P. Limaye et al. "Zonisamide: a review of the clinical and experimental evidence for its use in Parkinson's disease". Indian Journal of Pharmacology, 2013, 45 (6): 547–55).

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Shipping to USA, EU, Asia, Oceania and South America in October

Dear Customers! We ship to USA, to EU, to almost all countries by Japan Post OR Express Courier Service! Japan Post imposed restrictions on shipping to USA, EU and most of other coutnries. Situation changes every day. Please check this link for details on each country by Japan Post. https://www.post.japanpost.jp/int/information/overview_en.html We can ship to Most Countries. Please ask us on detail.  WE STILL CAN SHIP TO MOST COUNTRIES - SEE DETAILS BELOW OR CONTACT US IF YOU HAVE QUESTIONS!   USA: - EXPRESS SERVICE. We ship everything but vials. Delivery takes 6-10 days.  - SURFACE MAIL. We ship all other items (vials), takes 7-9 weeks or more, we offer tracking, Rate starts at 19-29 usd, free shipping for orders above 400 usd. If you can wait use this method. We can only ship vials and glass using surface mail.   EU - EUROPE We ship as usual (with possible delays) to the countries below (Alphabetic order):  Austria, Belgium, Bulgaria, Croatia, Czech, Denmark, Estonia, France (Monaco), Germany, Hungary, Italy, Latvia, Lithuania, Luxembourg, Netherlands (Holland), Norway, Poland, Portugal, Serbia, Slovenia, Spain, Sweden,     For other coutnries in Europe (Romania, Greece, Ukraine etc): We ship using express service to all other countries in EU at the moment. We can ship by express method for tablets and flat supplements in total weight not exceeding 0,5 kg. We ship in 7-12 business days. Delivery takes 6-10 days. USE EXPRESS METHOD. We can ship using surface mail. This takes 4-6 weeks or more, we offer tracking, Rate starts at 19 usd, free shipping for orders above 400 usd. If you can wait use this method. We can only ship vials and glass using surface mail.   ASIA - SINGAPORE, HONG KOG, KOREA, PHILIPPINES, TAIWAN, THAILAND, VIETNAM, MALAYSIA, PHILIPPINES. We ship as usual (with possible delays) to these countries   SHIPPING TO CHINA. We ship as usual by EMS or Surface mail.    SHIPPING TO INDIA. - WE STILL CAN SHIP TABLETS/CAPSULES. We can ship by express method for tablets and flat supplements in total weight not exceeding 0,5 kg. We ship in 7-12 business days. Delivery takes 8-14 days. USE EXPRESS METHOD. - WE SHIP BY SURFACE MAIL. This takes 4-6 weeks or more, we offer tracking, Rate starts at 19 usd, free shipping for orders above 400 usd. If you can wait use this method. We can only ship vials and glass using surface mail.   OCEANIA - AUSTRALIA. NEW ZEALAND To Australia: - WE STILL CAN SHIP TABLETS/CAPSULES. We can ship by express method for tablets and flat supplements in total weight not exceeding 0,5 kg. We ship in 7-12 business days. Delivery takes 8-14 days. USE EXPRESS METHOD. - WE SHIP BY SURFACE MAIL. This takes 4-6 weeks or more, we offer tracking, Rate starts at 19 usd, free shipping for orders above 400 usd. If you can wait use this method. We can only ship vials and glass using surface mail. TO NEW ZEALAND - WE SHIP AS USUAL    BRAZIL - WE STILL CAN SHIP TABLETS / CAPSULES / EYE DROPS. We can ship by express method for tablets and flat supplements in total weight not exceeding 0,5 kg. We ship in 7-12 business days. Delivery takes 8-14 days. USE EXPRESS METHOD. - WE SHIP BY SURFACE MAIL. This takes 4-6 weeks or more, we offer tracking, Rate starts at 19 usd, free shipping for orders above 400 usd. If you can wait use this method. We can only ship vials and glass using surface mail.   CANADA We ship as usual with delays due to reduced number of flights.   RUSSIA, UKRAINE, KAZAKHSTAN. - TO RUSSIA  WE SHIP ONLY BY SURFACE MAIL. This takes 5-6 weeks or more, we offer tracking, Rate starts at 19 usd, free shipping for orders above 400 usd. If you can wait use this method. We can only ship vials and glass using surface mail. - TO UKRAINE WE SHIP BY COURIER MAIL OR BY SURFACE MAIL.  - WE CAN SHIP TO KAZAKHSTAN BY AIRMAIL WITH DELAYS. 
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Reviews

John

Great product, original Japanese Lactis EL027826792JP
more ▶

Reviews

Mike

Good effect. I shall order again. Original made-in-japan package as promised EG401137451JP
more ▶

Reviews

May

Real Japanese laennec. Thank you! I shall order again. EJ377189782JP
more ▶

Reviews

Bob

Great effect! Got my hair back in 3 months. EG401137588JP
more ▶

Reviews

Nike

Lost 3 kilos since started to drink it last month. Great for fitness EG299855913JP
more ▶

Reviews

Any

Bought it for my son. Good effect and great service. EG299855961JP
more ▶

Reviews

Nya

Original touchi, fast delivery and good price. Thank you. EG401137156JP
more ▶

Reviews

Sam

Good medicine. Think it really helps me to fight cancer. EL025661542JP
more ▶

Reviews

John

3 times cheaper than in our country! And great effect for knees EJ365886698JP
more ▶

Reviews

Mike

Great thing to support diet. Lost 4 kilos for 6 weeks. Shall order more EJ365886675JP
more ▶