Tramal tablets 50 mg for cancer pain, postoperative and chronic pain (tramadol hydrochloride, Ultram)
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General information on Japanese Tramal tablets 50 mg for cancer pain and chronic pain (tramadol hydrochloride, Ultram)
Package details: 100 tablets
Manufacturer: Nippon Shinyaku Co., Ltd., Japan
Active ingredients: tramadol hydrochloride (chemical formula C16H25NO2)
Medical effect: Tramal tablets are effective for relieving severe pain, including cancer pain, postoperative pain and chronic pain that is non-responsive to non-opioid analgesics.
Contraindications and precautions: do not use for the following categories of patients:
- patients with acute intoxication caused by alcohol,
- patients taking sleeping pills, painkillers, opioid pain relievers or psychotropic drugs,
- patients with epilepsy or head injury with inadequate therapeutic management,
- patients who have used other drugs like monoamine oxidase inhibitor, drinking acid salt (Azilect), saffinamide mesylate (Ekfina) or nalmefene hydrochloride hydrate within the past 2 weeks,
- children under 12 years old
- patients under the age of 18 with obesity, obstructive sleep apnea syndrome or severe lung disease,
- pregnant or breastfeeding women.
As this medicine may cause dizziness or sleepiness, patient should avoid operating dangerous machinery, working at heights or driving a car while taking this medicine.
Avoid drinking alcohol while taking this medicine as it may intensify medical effects and adverse reactions.
If an allergic reaction occurs, stop using the medicine and consult with your doctor. If you’re taking any other medication or receiving any other treatment, you have to consult with your doctor before use.
Dosage and administration
For adults: take 2-6 tablets (100 to 300 mg of the active ingredient) a day, in 4 divided doses. The interval between the doses should be 4-6 hours. The doctor in charge may adjust the dosage according to the disease, age or symptoms. But the maximum dose of 100 mg at a time, 400 mg a day, should not be exceeded. For elderly people over 75 years old, the daily dose is usually up to 300 mg.
In case of acute worsening of cancer pain, patients should take 1/8 to 1/4 of their regular daily dose at a time as a rescue dose.
If the patient is taking this medicine for the first time, it is recommended to start with 25 mg. The tablets should be increased or decreased by the step of 25 mg. If a patient no longer needs this medicine, the dose should be reduced gradually.
When used for chronic pain, if the expected effect is not obtained in 4 weeks after the start of administration, a change to another treatment should be considered. When using for cancer pain, if the pain cannot be relieved even with 300 mg a day, a change to a strong opioid analgesic such as morphine should be considered.
Please note that this preparation contains 50 mg of the active ingredient in one tablet.
How effective are Tramal tablets 50 mg from Japan for cancer pain, postoperative and chronic pain (tramadol hydrochloride, Ultram)?
Tramal tablets contain tramadol hydrochloride, a strong opioid pain medication. With a 60-year history of use, it remains one of the most commonly prescribed medication in many countries all over the world. Tramadol hydrochloride works by binding to opioid receptor and inhibiting reuptake of monoamine.
Who should use Tramal tablets 50 mg from Japan?
Tramal tablets are effective for relieving severe pain, including cancer pain, postoperative pain and chronic pain that is non-responsive to non-opioid analgesics. Studies showed that the active ingredient’s metabolites are water-soluble and are excreted by kidneys, allowing to use in a reduced dose even for patients with kidney or liver disease (S. Grond, A. Sablotzki. Clinical pharmacology of tramadol // Clinical Pharmacokinetics, 2004, 43 (13): 879–923).