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Onetram tablets 100 mg for cancer and chronic pain (tramadol hydrochloride, Ultram, Tramal)
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General information on Japanese Onetram tablets 100 mg for cancer and chronic pain (tramadol hydrochloride, Ultram, Tramal)
Package details: 100 tablets
Manufacturer: Nippon Shinyaku Co., Ltd., Japan
Active ingredients: tramadol hydrochloride (chemical formula C16H25NO2)
Medical effect: Onetram tablets are effective for relieving severe pain, including cancer pain, postoperative pain and chronic pain that is non-responsive to non-opioid analgesics.
Contraindications and precautions: do not use for the following categories of patients:
- patients with acute intoxication caused by alcohol,
- patients taking sleeping pills, painkillers, opioid pain relievers or psychotropic drugs,
- patients with epilepsy or head injury with inadequate therapeutic management,
- patients who have used other drugs like monoamine oxidase inhibitor, drinking acid salt (Azilect), saffinamide mesylate (Ekfina) or nalmefene hydrochloride hydrate within the past 2 weeks,
- children under 12 years old
- patients under the age of 18 with obesity, obstructive sleep apnea syndrome or severe lung disease,
- patients with renal disorder or liver disorder,
- pregnant or breastfeeding women.
As this medicine may cause dizziness or sleepiness, patient should avoid operating dangerous machinery, working at heights or driving a car while taking this medicine.
Avoid drinking alcohol while taking this medicine as it may intensify medical effects and adverse reactions.
If an allergic reaction occurs, stop using the medicine and consult with your doctor. If you’re taking any other medication or receiving any other treatment, you have to consult with your doctor before use.
Dosage and administration
For adults: take 1-3 tablets (100 to 300 mg of the active ingredient) at a time, once a day. The doctor in charge may adjust the dosage according to the disease, age or symptoms. But the maximum dose of 400 mg a day should not be exceeded. For elderly people over 75 years old, the daily dose is usually up to 300 mg.
This medicine can not be used as a rescue dose, in case of sudden cancer pain exacerbation. If the patient needs a rescue dose, they should take a different take tramadol hydrochloride immediate release preparation.
The tablet should be swallowed without splitting, crushing or chewing.
How effective are Onetram tablets 100 mg from Japan for cancer and chronic pain (tramadol hydrochloride, Ultram, Tramal)?
Onetram tablets contain tramadol hydrochloride, a strong opioid pain medication, working by binding to opioid receptor and inhibiting reuptake of monoamine. With a 60-year history of use, it remains one of the most commonly prescribed medication in many countries all over the world. However, this medicine uses a new patented technology by Endo and Pfizer, with a dual structure of the peripheral part with immediate release and the central part with sustained release. This structure makes Onetram tablets’ effect immediate and durable.
Who should use Onetram tablets 100 mg from Japan?
Onetram tablets are effective for relieving severe pain, including cancer pain, postoperative pain and chronic pain that is non-responsive to non-opioid analgesics. Studies showed that sustained release formulation allows tramadol to achieve stable serum levels without marked peak to trough fluctuations and reduced frequency of dosing (S. S. Khandave, S. V. Sawant et al. “Comparative bioequivalence studies of tramadol hydrochloride sustained-release 200 mg tablets”. Drug Design, Development and Therapy, 2010; 4: 367–374).