Takecab tablets 10 mg for ulcer and reflux esophagitis (vonoprazan fumarate)

General information on Japanese Takecab tablets 10 mg for ulcer and reflux esophagitis (vonoprazan fumarate)

Package details: 100 tablets

Manufacturer: Takeda Pharmaceutical Co., Ltd., Japan

Active ingredients: vonoprazan fumarate (chemical formula C18H20N3NaO3S)

Medical effect: Takecab tablets are effective for the following purposes:

• treatment of gastric ulcer,
• treatment of duodenal ulcer,
• treatment of reflux esophagitis,
• suppression of recurrence of gastric or duodenal ulcer associated with low-dose aspirin or nonsteroidal anti-inflammatory drug medication,
• eradication of Helicobacter pylori.

Contraindications and precautions: do not use for pregnant or breastfeeding women. Do not use for patients with liver or renal disorder.  

If an allergic reaction occurs, stop taking the medicine and consult with your doctor. If you’re taking any other medication or receiving any other treatment, you have to consult with your doctor before use.

Dosage and administration of Takecab tablets 10 mg from Japan for ulcer and reflux esophagitis (vonoprazan fumarate)

 For gastric or duodenal ulcer or reflux esophagitis: for adults, take 2 tablets (20 mg of active ingredient) at a time, once a day. The course of treatment with this medicine should be within 8 weeks for gastric ulcer, 6 weeks for duodenal ulcer and 4 weeks for reflux esophagitis. If the effect is insufficient, the treatment may be continued for up to 8 weeks.

For maintenance therapy for repeatedly relapsing reflux esophagitis: for adults, take 1 tablet (10 mg) at a time, once a day. If the effect is insufficient, the dosage may be increased to 2 tablets (20 mg) at a time.

For suppression of recurrence of gastric or duodenal ulcers associated with low-dose aspirin or non-steroidal anti-inflammatory drug therapy: for adults, take 1 tablet (10 mg) at a time, once a day.

How effective are Takecab tablets 10 mg from Japan for ulcer and reflux esophagitis (vonoprazan fumarate)?

Takecab tablets contain vonoprazan fumarate, a potassium-competitive acid blocker, the first in in its class. It works by inhibiting the proton pump in a potassium ion-competitive manner to reduce gastric acid secretion in the stomach. Studies showed that Takecab tablets increase intragastric pH in only 4 hours after the first intake, and during the course of treatment intragastric pH holding time significantly extends (H. Echizen "The First-in-Class Potassium-Competitive Acid Blocker, Vonoprazan Fumarate: Pharmacokinetic and Pharmacodynamic Considerations". Clinical Pharmacokinetics, 2016, 55 (4): 409–18).

Who should use Takecab tablets 10 mg from Japan?

Takecab tablets are effective for the treatment of gastric or duodenal ulcer, reflux esophagitis and for suppression of recurrence of gastric or duodenal ulcer associated with low-dose aspirin or nonsteroidal anti-inflammatory drug medication. In a combination with clarithromycin and amoxicillin this medicine also helps to eradicate Helicobacter Pylori.