Sigmart injections 12 mg for angina (nicorandil)

General information on Japanese Sigmart injections 12 mg for angina (nicorandil)     

Package details: 10 vials

Manufacturer: Chugai Pharmaceutical Co., Ltd., Japan

Active ingredient: nicorandil (chemical formula C8H9N3O4)

Medical effect: Sigmart injections are effective for the treatment of the following diseases and conditions:

• chest pain,
• chest oppressive feeling,
• unstable angina pectoris,
• acute heart failure.

Contraindications and precautions: do not use in pregnant and breastfeeding women. Do not use in patients with hepatic dysfunction, renal dysfunction, cerebral dysfunction, hypotension, cardiogenic shock, Eisenmenger syndrome, primary pulmonary hypertension, right ventricular infarction, symptom of dehydration, neurocirculatory asthenia, glaucoma, left ventricular outflow tract stenosis in acute heart failure, hypertrophic obstructive cardiomyopathy or aortic valve stenosis.

Never take sildenafil citrate (Viagra), vardenafil hydrochloride hydrate (Levitra) or tadalafil (Cialis) while taking this medication.

If an allergic reaction occurs, stop using the medication and consult with your doctor. If you’re taking any other medication, please consult with your doctor before use.

Dosage and administration of Sigmart injections 12 mg from Japan for angina (nicorandil)

For angina pectoris: In general, inject with intravenous infusion.

For heart failure: In general, inject continuously and intravenously.

The treatment period with this medicine depends on the patient’s response to the treatment. The dosage may be adjusted by the consulting doctor according to age, body weight and symptoms.

How effective are Japanese Sigmart injections 12 mg for angina (nicorandil)?

Nicorandil is a nicotinamide ester working as nitrate and ATP-sensitive K+ channel agonist.Sigmart injections with nicorandil decrease the calcium sensitivity of the smooth muscle and relax smooth muscle resulting in coronary vasodilation. This medicine helps to dilate both normal and stenotic coronary arteries.

Who should use Sigmart injections 12 mg from Japan?

Sigmart injections are effective for the coronary vasodilation in patients with acute angina pectoris and for decreasing the heart burden in patients with heart failure. Studies showed that intravenous nicorandil is effective for both patients with unstable angina and variant angina, even helping with patients who are refractory to therapy with conventional antianginal agents (J. Frampton, M. M. Buckley, A. Fitton. “Nicorandil. A review of its pharmacology and therapeutic efficacy in angina pectoris”. Drugs. 1992, October, 44 (4): 625-55).