Kremezin tablets 500 mg for progressive chronic renal failure

General information on Japanese Kremezin tablets 500 mg for progressive chronic renal failure

Package details: 336 tablets

Manufacturer: Mitsubishi Tanabe Pharma, Japan

Active ingredient: carbon adsorbent obtained by oxidizing and reducing at high temperature activated carbon derived from hydrocarbon 500 mg

Medical effect: Kremezin tablets adsorb uremic toxins and their precursors in gastrointestinal tract, improve the uremic symptoms and delay the progress of chronic renal failure.

Contraindications and precautions:

Do not use in patients with transit disorder in the digestive tract. Do not use in pregnant or breastfeeding women. If allergic reaction occurs, stop using the product and consult with your doctor.

Dosage and administration of Japanese Kremezin tablets 500 mg for progressive chronic renal failure

Take 4 tablets in one packet (2 g of the active ingredient) 3 times a day. Allow tablet to disintegrate with small amount of water in your mouth, then swallow it with water. If you are currently taking any other medicines, take Kremezin tablets 30 minutes to 1 hour after the other medicine.

How effective are Kremezin tablets 500 mg for progressive chronic renal failure from Japan?

Kremezin tablets contain a carbon absorbent obtained by oxidizing and reducing at high temperature activated carbon, derived from hydrocarbon. These tablets adsorb uremic toxins such as indoxyl sulfate and p-cresyl sulfate and the toxins’ precursors in the gastrointestinal tract and help to exert those with fecal masses. Studies show that Kremezin tablets delay the decline in renal function and prolong the time to the initiation of dialysis, especially in patients with progressive chronic kidney disease (M. Asai, S. Kamakura, M. Kikuchi. Review of the efficacy of AST-120 (KREMEZIN®) on renal function in chronic kidney disease patients. Renal Failure, 2019; 41(1): 47–56).

Who should use Kremezin tablets 500 mg for progressive chronic renal failure?

Kremezin tablets are effective for treatment of patients with progressive chronic kidney disease. They improve such uremic symptoms as:

• loss of appetite,
• weakness,
• insomnia,
• bad breath,
• headache,
• nausea,
• itchiness.

Moreover, tablets delay initiation of dialysis so we particularly recommend using them for patients who are not receiving hemodialysis yet.