Kremezin fine granules 2 g for progressive chronic renal failure

General information on Japanese Kremezin fine granules 2 g for progressive chronic renal failure

Package details: 84 packs * 2 g

Manufacturer: Mitsubishi Tanabe Pharma, Japan

Active ingredient: carbon adsorbent obtained by oxidizing and reducing at high temperature activated carbon derived from hydrocarbon 2 g

Medical effect: Kremezin fine granules adsorb uremic toxins and their precursors in gastrointestinal tract, improve the uremic symptoms and delay the progress of chronic renal failure.

Contraindications and precautions:

Do not use in patients with transit disorder in the digestive tract. Do not use in pregnant or breastfeeding women. If allergic reaction occurs, stop using the product and consult with your doctor.

Dosage and administration of Japanese fine granules 2 g for progressive chronic renal failure

For adults: take 1 packet (2 g of the active ingredient) at a time, 3 times a day. If you are currently taking any other medicines, take Kremezin granules 30 minutes to 1 hour after the other medicine.

How effective are Kremezin fine granules 2 g for progressive chronic renal failure from Japan?

Kremezin fine granuless contain a carbon absorbent obtained by oxidizing and reducing at high temperature activated carbon, derived from hydrocarbon. These granules adsorb uremic toxins such as indoxyl sulfate and p-cresyl sulfate and the toxins’ precursors in the gastrointestinal tract and help to exert those with fecal masses. Studies show that Kremezin delays the decline in renal function and prolongs the time to the initiation of dialysis, especially in patients with progressive chronic kidney disease (M. Asai, S. Kamakura, M. Kikuchi. Review of the efficacy of AST-120 (KREMEZIN®) on renal function in chronic kidney disease patients. Renal Failure, 2019; 41(1): 47–56).

Who should use Kremezin fine granules 2 g for progressive chronic renal failure?

Kremezin granules are effective for treatment of patients with progressive chronic kidney disease. They improve such uremic symptoms as:

• loss of appetite,
• weakness,
• insomnia,
• bad breath,
• headache,
• nausea,
• itchiness.

Moreover, Kremezin delays initiation of dialysis so it is particularly recommended for patients who are not receiving hemodialysis yet. Kremezin is available in 2 forms: granules and tablets. The effectiveness remains the same, and the form should be chosen considering patient’s intake feeling and medication adherence.