Carvedilol tablets 1.25 mg for chronic heart failure (Coreg, Artist)

General information on Japanese Carvedilol tablets 1.25 mg for chronic heart failure (Coreg, Artist)

Package details: 100 tablets

Manufacturer: Sawai Pharmaceutical Co. Ltd. / Mitsubishi Tanabe Pharma Co., Ltd., Japan

Active ingredients: carvedilol (chemical formula C24H26N2O4)

Medical effect: Carvedilol tablets are effective for the treatment of chronic heart failure due to ischemic heart disease or dilated cardiomyopathy.

Contraindications and precautions: do not use for the following categories of patients:

• Carvedilol tablets cannot be used for patients with bronchial asthma or bronchospastic conditions as it may provoke bronchospasm,
• Patients with diabetic ketoacidosis or metabolic acidosis,
• Patients with bradycardia, atrioventricular block, sinoatrial block, cardiogenic shock, decompensated heart failure, right heart failure due to pulmonary hypertension or untreated pheochromocytoma,
• Pregnant, breastfeeding or possibly pregnant women.

If an allergic reaction occurs, stop taking the medicine and consult with your doctor. If you’re taking any other medication or receiving any other treatment, you have to consult with your doctor before use.

As this medicine may provoke the sudden dizziness, the patient should avoid working at heights, operating dangerous machinery, or driving a car.

Dosage and administration

For adults, start with 1 tablet (1.25 mg of the active ingredient) at a time, 2 times a day after meals. If this medicine is tolerated well, the dosage may be gradually increased gradually at intervals of at least 1 week between each step. If at some point the dose is not tolerated well, the dosage may be reduced.

The dosage must be increased or decreased step by step, with 1 tablet (1.25 mg), 2 tablets (2.5 mg), 4 tablets (5 mg) or 8 tablets (10 mg) taken at a time, 2 times a day after meals. A maintenance dose is 2 to 8 tablets (2.5 mg to 10 mg) at a time, 2 times a day after meals.

How effective are Carvedilol tablets 1.25 mg from Japan for chronic heart failure (Coreg, Artist)?

Carvedilol is a non-selective β-adrenergic receptor antagonist and an α-adrenergic receptor antagonist. By blocking adrenergic receptors, it suppresses excess activity of the heart and improves cardiac functions. As an alpha blocker, Carvedilol tablets also help to widen the blood vessels and, by this, to decrease the blood pressure.

Who should use Carvedilol tablets 1.25 mg from Japan?

Carvedilol tablets are effective for the treatment of chronic heart failure due to ischemic heart disease or dilated cardiomyopathy. Studies showed that carvedilol helps to regulate the heartbeat, prevents the heart attacks and significantly reduces the risk of death (H. J. Dargie. "Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial". The Lancet, 2001, 357 (9266): 1385–1390).