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Oncology and cancer

Reviews

John

Great product, original Japanese Lactis EL027826792JP
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Reviews

Mike

Good effect. I shall order again. Original made-in-japan package as promised EG401137451JP
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Reviews

May

Real Japanese laennec. Thank you! I shall order again. EJ377189782JP
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Reviews

Bob

Great effect! Got my hair back in 3 months. EG401137588JP
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Reviews

Nike

Lost 3 kilos since started to drink it last month. Great for fitness EG299855913JP
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Reviews

Any

Bought it for my son. Good effect and great service. EG299855961JP
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Reviews

Nya

Original touchi, fast delivery and good price. Thank you. EG401137156JP
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Reviews

Sam

Good medicine. Think it really helps me to fight cancer. EL025661542JP
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Reviews

John

3 times cheaper than in our country! And great effect for knees EJ365886698JP
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Reviews

Mike

Great thing to support diet. Lost 4 kilos for 6 weeks. Shall order more EJ365886675JP
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Home Japanese Supplements Oncology and cancer
Calsed (amrubicin) 50 mg 1 vial
Calsed (amrubicin) 50 mg 1 vial
Product Code Amrb
Availability 10
Price USD 389.00
Qty
Buy now Guarantee Contact as

Calsed (amrubicin) 50 mg 1 vial

Product Code : Amrb

Availability : 10

USD 389.00

Buy now

Basic information on Amrubicin for lung cancer

Active component: amrubicin hydrochloride 50 mg

Application: treatment of lung cancer.

Dosage and administration: follow the instructions of the attending physician.

Contraindications and precautions: strictly follow the dosage. In case of complications, discontinue the drug treatment.

Amrubicin is a third-generation lung cancer medicine from Japan. The drug is distributed in Japan since 2005 by Nippon Kayaku.

Pharmacodynamics of Amrubicin.

The anthracycline glycoside group of antibiotics, including amrubicin, is a group of potent anti-cancer agents with strong activity against both solid tumors and hematological malignancies. Amrubicin is a derivative of 9-aminoanthracycline and contributes to the inhibition of cell growth by stabilizing protein-DNA complexes, followed by double-stranded DNA breaks, which are mediated by the enzyme topoisomerase II

The mechanism of action of Amrubicin.

As anthracycline, amrubicin has antimitotic and cytotoxic activity through various mechanisms of action. Amrubicin has been found to form complexes with DNA by intercalation between base pairs and inhibits the activity of the enzyme topoisomerase II by stabilizing the DNA-topoisomerase II complex, which prevents the ligation-re-polymerization reaction, which usually catalyzes the topoisomerase II

Toxicity of Amrubicin

Based on acute toxicity studies of intravenous doses, the lethal dose of up to 50% of animals was estimated at 42 mg / kg in mice, 14 mg / kg in rats and 4 mg / kg for dogs

Clinical trials and Research on Amrubicin.

The drug has been studied in numerous studies in Japan and in the west. You can check at lease several studies on this medicine:

  1. The article “Pharmacokinetics of amrubicin in patients with lung cancer with impaired liver function” (Pharmacokinetics of the amrubicin in lung cancer patients with impaired hepatic function) provides a detailed study of the pharmacokinetics of the drug and its methods for the treatment of specific diseases.
  2. The same drug is prescribed as an orphan drug by the US Department of Health (FDA) for the treatment of lung cancer - you can find relevant information here (Amrubicin Receives FDA orphan drug status).
  3. Professors Kurata T, Okamoto I, Tamura K, Fukuoka M conducted a fundamental collective study of the efficacy and methods of using this drug in their monograph (Amrubicin for non-small-cell lung cancer).

Related articles and information.

We are here to help, please feel free to ask any question. You can also check the following articles related to oncology and cancer treatment in Japan in our blog below:

Agaricus and oncology treatment: questions and answers.

Five Japanese medicines for oncology treatment

Japanese cancer and oncology medicines.

Hugo | 3 reviews
Ordered 5 ampules for studies. Disappointed that you don't have any discounts for the researches.
Ryder | 3 reviews
Dad got worse suddenly, he passed away 3 days after this medicine was sent. Now I don't know what to do, it's so expensive and I cannot even resale it. Can we turn it back please? It's completely unused.
Sandra | 3 reviews
Received the parcel, hope it works. So expensive!

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News

Shipping to USA, EU, Asia, Oceania and South America in April

Notification from 1st April 2021 - Regarding shipping in Pandemic and Japan Post Stop Act. Dear Customers!   WE CAN SHIP to USA, EU, UAE, Australia, New Zealand, Canada, Hong-Kong, China, Korea, Vietnam, Mexico and all other countries!   Japan Post imposed restrictions on shipping to most of other coutnries. Situation changes eevry day, you can find latest news here - https://www.post.japanpost.jp/int/information/index_en.html Please use search on page to find your country.   IF JAPAN POST DOES NOT SHIP OR SHIPS BY SURFACE MAIL ONLY WE CAN SHIP BY COURIER.   For shiping by Japan Post check this link with full list of countries https://www.post.japanpost.jp/int/information/overview_en.html For shipping by Сourier check table below or contact us as situation changes every day.   SEE TABLE BELOW. SEE COMMENTS BELOW TABLE IF YOU CAN NOT FIND YOUR COUNTRY -- CONTACT US! W CAN SHIP. Shipping type Economy Mail ** Express Service Methods: * SURFACE AIRMAIL Courier05 *** EMS  Argentina NO YES YES YES Armenia YES  YES YES NO Australia YES  YES YES NO Austria YES  YES YES YES Azerbaijan YES  YES YES NO Belarus YES  YES YES NO Belgium YES  YES YES YES Brazil YES NO YES NO Bulgaria YES  YES YES YES Canada YES  YES YES NO Chile NO YES YES YES China YES  YES YES YES Colombia NO YES YES YES Congo YES NO YES NO Costa Rica YES NO YES NO Croatia YES  YES YES YES Cyprus NO YES YES YES Czech YES  YES YES YES Denmark YES  YES YES YES Ecuador NO NO YES NO Egypt YES YES YES NO Estonia YES  YES YES YES Finland YES  YES YES YES France YES  YES YES YES Georgia YES NO YES NO Germany YES  YES YES YES Great Britain YES  YES YES YES Greece YES  NO YES NO Hungary YES  YES YES YES India YES  NO YES NO Indonesia YES  YES YES YES Iran / Iraq NO YES  NO YES Ireland YES YES YES YES Israel YES NO YES NO Italy YES  YES YES YES Kazakhstan YES  YES NO NO Kenya NO YES YES YES Laos YES NO YES NO Latvia YES  YES YES YES Liechtenstein YES  YES YES YES Lithuania YES  YES YES YES Luxemurbg YES  YES YES YES Malaysia YES  NO YES NO Mexico YES  YES YES YES Moldova YES NO YES NO Mongolia NO NO YES NO New Zealand YES  YES YES YES Norway YES  YES YES YES Pakistan NO YES YES YES Panama NO NO YES NO Peru YES NO YES NO Poland YES  YES YES YES Portugal YES  YES YES YES Romania YES  NO YES NO Russia YES NO NO (ASK US) NO Saudi Arabia YES NO YES NO Serbia YES  YES YES NO Slovakia YES  YES YES NO Spain YES  YES YES YES Sri Lanka YES  YES YES YES Sweden YES  YES YES YES Switzerland YES  YES YES YES Tajikistan YES NO YES NO Turkey YES  YES YES YES UAE (Dubai) YES  NO YES NO Ukraine YES YES NO YES USA YES  YES* YES NO Uzbekistan YES NO YES NO Vietnam YES  YES YES YES           * We select appropriate available method. If you need specific method contact us. ** Economy mail is shipped by Air if airmail is available, if not we ship by Surface mail. There are restrictions applied by Japan Post. *** Courier-05, shipping for parcels with tablets up to 5 boxes (most cases), vials 10-20 pcs drops up to 0,5 kg in weight. Can ship to specific regions/cities, please check before order. IF YOU DO NOT SEE COUNTRY ON LIST, CONTACT US!   USA: - EXPRESS SERVICE. We ship by express, Delivery takes 8-12 days.  - AIRMAIL MAIL. If you prefer economy mail, we ship by surface mail, takes 2-4 weeks, no tracking, only local number in Japan, Rate starts at 29 usd, free shipping for orders above 400 usd and 2 kg. If you can wait use this method.   EU - EUROPE We ship as usual to all countries besides Greece, Romania, Moldova and Russia.  For Romania, Greece and Moldova: We ship using express service to all other countries in EU at the moment. Or by surface mail.   ASIA - SINGAPORE, HONG KOG, KOREA, TAIWAN, THAILAND, VIETNAM, MALAYSIA, PHILIPPINES. We ship as usual (with possible delays) to these countries   SHIPPING TO CHINA. We ship as usual by EMS or Airmail.    SHIPPING TO INDIA. - WE CAN SHIP BY COURIER. We can ship by express method almost everything. Delivery takes 8-14 days. USE EXPRESS METHOD. - WE SHIP BY SURFACE MAIL. This takes 6-8 weeks or more, we offer tracking, Rate starts at 19 usd, free shipping for orders above 400 usd. If you can wait use this method. We can only ship vials and glass using surface mail.   OCEANIA - AUSTRALIA. NEW ZEALAND To Australia: - EXPRESS SERVICE. We ship by express, Delivery takes 8-12 days.  - AIRMAIL MAIL. If you prefer economy mail, we ship by surface mail, takes 2-4 weeks, no tracking, only local number in Japan, Rate starts at 29 usd, free shipping for orders above 400 usd and 2 kg. If you can wait use this method. TO NEW ZEALAND - WE SHIP AS USUAL    BRAZIL - WE CAN SHIP BY COURIER. We can ship by express method almost everything. Delivery takes 8-14 days. USE EXPRESS METHOD. - WE SHIP BY SURFACE MAIL. This takes 10-15 weeks or more, we offer tracking, Rate starts at 19 usd, free shipping for orders above 400 usd. If you can wait use this method. We can only ship vials and glass using surface mail.   CANADA - EXPRESS SERVICE. We ship by express, Delivery takes 8-12 days.  - AIRMAIL MAIL. If you prefer economy mail, we ship by surface mail, takes 2-4 weeks, no tracking, only local number in Japan, Rate starts at 29 usd, free shipping for orders above 400 usd and 2 kg. If you can wait use this method.   UKRAINE, KAZAKHSTAN. RUSSIA. - WE CAN SHIP TO KAZAKHSTAN AND UKRANE as usual by  AIRMAIL WITH POSSIBLE DELAYS. EMS and courier is available for Ukraine.  - Only surface mail is allowed for Russia due to strict customs control for all other methods.
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Reviews

John

Great product, original Japanese Lactis EL027826792JP
more ▶

Reviews

Mike

Good effect. I shall order again. Original made-in-japan package as promised EG401137451JP
more ▶

Reviews

May

Real Japanese laennec. Thank you! I shall order again. EJ377189782JP
more ▶

Reviews

Bob

Great effect! Got my hair back in 3 months. EG401137588JP
more ▶

Reviews

Nike

Lost 3 kilos since started to drink it last month. Great for fitness EG299855913JP
more ▶

Reviews

Any

Bought it for my son. Good effect and great service. EG299855961JP
more ▶

Reviews

Nya

Original touchi, fast delivery and good price. Thank you. EG401137156JP
more ▶

Reviews

Sam

Good medicine. Think it really helps me to fight cancer. EL025661542JP
more ▶

Reviews

John

3 times cheaper than in our country! And great effect for knees EJ365886698JP
more ▶

Reviews

Mike

Great thing to support diet. Lost 4 kilos for 6 weeks. Shall order more EJ365886675JP
more ▶