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Oncology and cancer

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John

Great product, original Japanese Lactis EL027826792JP
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Mike

Good effect. I shall order again. Original made-in-japan package as promised EG401137451JP
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May

Real Japanese laennec. Thank you! I shall order again. EJ377189782JP
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Bob

Great effect! Got my hair back in 3 months. EG401137588JP
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Nike

Lost 3 kilos since started to drink it last month. Great for fitness EG299855913JP
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Any

Bought it for my son. Good effect and great service. EG299855961JP
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Nya

Original touchi, fast delivery and good price. Thank you. EG401137156JP
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Sam

Good medicine. Think it really helps me to fight cancer. EL025661542JP
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John

3 times cheaper than in our country! And great effect for knees EJ365886698JP
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Mike

Great thing to support diet. Lost 4 kilos for 6 weeks. Shall order more EJ365886675JP
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Home Japanese Supplements Oncology and cancer
Calsed (amrubicin) 50 mg 1 vial.
Calsed (amrubicin) 50 mg 1 vial.
Product Code Amrb
Availability 10
Price USD 329.00
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Calsed (amrubicin) 50 mg 1 vial.

Product Code : Amrb

Availability : 10

USD 329.00

Buy now

Basic information on Amrubicin for lung cancer.

Active component: amrubicin hydrochloride 50 mg

Application: treatment of lung cancer.

Dosage and administration: follow the instructions of the attending physician.

Contraindications and precautions: strictly follow the dosage. In case of complications, discontinue the drug treatment.

Amrubicin is a third-generation lung cancer medicine from Japan. The drug is distributed in Japan since 2005 by Nippon Kayaku.

Pharmacodynamics of Amrubicin.

The anthracycline glycoside group of antibiotics, including amrubicin, is a group of potent anti-cancer agents with strong activity against both solid tumors and hematological malignancies. Amrubicin is a derivative of 9-aminoanthracycline and contributes to the inhibition of cell growth by stabilizing protein-DNA complexes, followed by double-stranded DNA breaks, which are mediated by the enzyme topoisomerase II

The mechanism of action of Amrubicin.

As anthracycline, amrubicin has antimitotic and cytotoxic activity through various mechanisms of action. Amrubicin has been found to form complexes with DNA by intercalation between base pairs and inhibits the activity of the enzyme topoisomerase II by stabilizing the DNA-topoisomerase II complex, which prevents the ligation-re-polymerization reaction, which usually catalyzes the topoisomerase II

Toxicity of Amrubicin

Based on acute toxicity studies of intravenous doses, the lethal dose of up to 50% of animals was estimated at 42 mg / kg in mice, 14 mg / kg in rats and 4 mg / kg for dogs

Clinical trials and Research on Amrubicin.

The drug has been studied in numerous studies in Japan and in the west. You can check at lease several studies on this medicine:

  1. The article “Pharmacokinetics of amrubicin in patients with lung cancer with impaired liver function” (Pharmacokinetics of the amrubicin in lung cancer patients with impaired hepatic function) provides a detailed study of the pharmacokinetics of the drug and its methods for the treatment of specific diseases.
  2. The same drug is prescribed as an orphan drug by the US Department of Health (FDA) for the treatment of lung cancer - you can find relevant information here (Amrubicin Receives FDA orphan drug status).
  3. Professors Kurata T, Okamoto I, Tamura K, Fukuoka M conducted a fundamental collective study of the efficacy and methods of using this drug in their monograph (Amrubicin for non-small-cell lung cancer).

Related articles and information.

We are here to help, please feel free to ask any question. You can also check the following articles related to oncology and cancer treatment in Japan in our blog below:

Agaricus and oncology treatment: questions and answers.

Five Japanese medicines for oncology treatment

Japanese cancer and oncology medicines.

| 1 reviews
Received the parcel, hope it works. So expensive!

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News

Shipping to USA and EU etc.

Dear Customers! Japan Post imposed mass restrictions on shipping to USA and EU. Please check this link for details on each country. https://www.post.japanpost.jp/int/information/2020/0423_01_en.html   SHIPIPNG TO U.S.A.: - WE STILL CAN SHIP TABLETS/CAPSULES. We can ship by express method for tablets and flat supplements in total weight not exceeding 0,5 kg. We ship in 7-12 business days. Delivery takes 6-10 days. USE EXPRESS METHOD. - WE SHIP BY SURFACE MAIL. This takes 4-6 weeks or more, we offer tracking, Rate starts at 19 usd, free shipping for orders above 400 usd. If you can wait use this method. We can only ship vials and glass using surface mail. -  some parcels were shipped to USA but are stuck in Japan. Japan Post officially admitted that they will take too long to ship. We are returning parcels. We shall ship by another method and advice tracking after Golden Week. You do not need to pay second shipping fee.  https://www.post.japanpost.jp/int/information/2020/0423_03_en.html   SHIPPING TO EU. Airmail service works only to UK and Germany. Japan Post accept orders to France and Netherlands, but may take very long time to ship. We ship using express service to all other countries in EU at the moment. We can ship by express method for tablets and flat supplements in total weight not exceeding 0,5 kg. We ship in 7-12 business days. Delivery takes 6-10 days. USE EXPRESS METHOD. We can ship using surface mail. This takes 4-6 weeks or more, we offer tracking, Rate starts at 19 usd, free shipping for orders above 400 usd. If you can wait use this method. We can only ship vials and glass using surface mail. - some parcels were shipped to EU in April but are stuck in Japan. Japan Post officially admitted that they will return parcel. We shall reship by another method and advice tracking after Golden Week. You do not need to pay second shipping fee.   SHIPPING TO SINGAPORE, HONG KOG, KOREA. We ship as usual but there will be delays. Please select surface mail, we shall ship by Airmail. Make sure you can wait.   SHIPPING TO CHINA. We can ship to China some categories of goods (tablets/supplements/capsules) at the moment, please contact us on details.
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Reviews

John

Great product, original Japanese Lactis EL027826792JP
more ▶

Reviews

Mike

Good effect. I shall order again. Original made-in-japan package as promised EG401137451JP
more ▶

Reviews

May

Real Japanese laennec. Thank you! I shall order again. EJ377189782JP
more ▶

Reviews

Bob

Great effect! Got my hair back in 3 months. EG401137588JP
more ▶

Reviews

Nike

Lost 3 kilos since started to drink it last month. Great for fitness EG299855913JP
more ▶

Reviews

Any

Bought it for my son. Good effect and great service. EG299855961JP
more ▶

Reviews

Nya

Original touchi, fast delivery and good price. Thank you. EG401137156JP
more ▶

Reviews

Sam

Good medicine. Think it really helps me to fight cancer. EL025661542JP
more ▶

Reviews

John

3 times cheaper than in our country! And great effect for knees EJ365886698JP
more ▶

Reviews

Mike

Great thing to support diet. Lost 4 kilos for 6 weeks. Shall order more EJ365886675JP
more ▶