Adecut tablets 15 mg for hypertension (delapril)

General information on Japanese Adecut tablets 15 mg for hypertension (delapril)

Package details: 100 tablets

Manufacturer: Teva Takeda Yakuhin Ltd, Japan

Active ingredient: delapril hydrochloride (chemical formula C26H33ClN2O5)

Medical effect: Adecut tablets are effective for the treatment of hypertension.

Contraindications and precautions: do not use for the following categories of patients:

• pregnant, possibly pregnant or breastfeeding women,
• patients with history of angioedema,
• patients on apheresis with an adsorber, or on hemodialysis,
• patients with a renal disease, hyperkalemia, or cerebrovascular disorder,
• patients on low-salt diet therapy,
• patients in preoperative state.

As this medicine may cause dizziness due to rapid  lowering of blood pressure, patient should pay close attention when driving a car or operating dangerous mechanisms while taking this medicine.

If an allergic reaction occurs, stop taking the medicine and consult with your doctor. If you’re taking any other medication, please consult with your doctor before use.

Dosage and administration

For adults: start with taking 0.5 tablet (7.5 mg) at a time, 2 times a day, in the morning and in the evening. Then gradually increase the dosage to 1-2 tablets at a time, 2 times a day, in the morning and evening. When a stable effect is achieved, the medicine may be taken daily dose or half dose, once a day, in the morning. The doctor in charge may adjust the dosage according to patient's age and symptoms. However, the maximum daily dosage of 4 tablets (60 mg) at a time, 2 a day, should not be exceeded.

How effective are Adecut tablets 15 mg from Japan for hypertension (delapril)?

Adecut tablets contain delapril, a prodrug that converts in the body into two angiotensin-converting-enzyme inhibitors. Those metabolites inhibit the activity of the enzyme converting angiotensin I to angiotensin II and, by this, decrease the formation of angiotensin II, a vasoconstrictor, and increase the level of bradykinin, a peptide vasodilator. As the result, Adecut tablets relax the blood vessels, decrease the blood volume and lower blood pressure.

Who should take Adecut tablets 15 mg from Japan?

Adecut tablets are effective for the treatment of hypertension. Delapril was developed in Japan by Takeda Chemical Industries Group. Clinical studies showed that it has 73% efficacy for essential hypertension, 85% for renal hypertension, and 80% for renovascular hypertension (T. Ogihara, Y. Kaneko et al. “Clinical evaluation of delapril in Japan. Report from the Japan Study Group on Delapril” // American journal of hypertension. 1991, 4(1 Pt 2):42S-45S).