Bonoteo tablets 1 mg for osteoporosis.

General information on Japanese Bonoteo tablets 1 mg for osteoporosis

Package details: 100 tablets

Manufacturer: Astellas Pharma Inc., Japan

Active ingredient: minodronic acid hydrate (chemical formula C9H14N2O8P2)

Medical effect: Bonoteo tablets inhibit activity of farnesyl pyrophosphate synthase, by this, inhibiting osteoclastic bone resorption. They increase bone density and strength and prevent bone fracture.

Contraindications and precautions:

Bonoteo tablets cannot be used for the following categories of patients:

• patients with disorder that delays esophageal transit, for example, esophageal stenosis,
• patients unable to sit upright for more than 30 minutes,
• patients with hypocalcemia,
• pregnant or breastfeeding women.

Dosage and administration of Japanese tablets Bonoteo 1 mg for osteoporosis

Take 1 tablet 1 time a day with approximately 180 mL of water, strictly before the first meal or beverage of the day. At least for the first 30 minutes after taking the tablet, refrain from lying down, eating, drinking (including mineral water) or taking other medicine, except drinking usual water.

Never take this medicine after consuming any food or beverages. If you missed the dose and have already had some foods and beverages, skip the missed dose and continue regular intake from the next morning.

Do not crunch or dissolve the medicine in the mouth as it might cause irritation in the mouth or throat. Do not take the medicine at bedtime or before rising. Make sure to take enough calcium and vitamin D from food or vitamin supplements.

How effective are Bonoteo tablets 1 mg for osteoporosis from Japan?

Bonoteo tablets contain 1 mg of minodronic acid hydrate, bisphosphonate that inhibits activity of farnesyl pyrophosphate synthase. Thus, Bonoteo tablets inhibit osteoclastic bone resorption, 1000 times more effective than etidronic acid and 10 to 100 times more effective than alendronic acid. This medicine decreases the incidence rate of new vertebral and nonvertebral fractures. In other words, it is effective for preventing bone fracture.

Who should use Bonoteo tablets 1 mg for osteoporosis?

Studies show that Bonoteo tablets are effective for increasing bone density and strength in patients with osteoporosis of different aetiology, like postmenopausal osteoporosis or steroid-induced osteoporosis (for example, see S. Tanishima, Y. Morio. A review of minodronic acid hydrate for the treatment of osteoporosis. Clinical interventions in aging, 2013, 8:185-9). Also, this medicine can be used both for primary osteoporosis and secondary osteoporosis.