Zithromac powder for IV solution 500 mg (Zithromax, azithromycin, antibiotic)
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General information on Japanese Zithromac powder for IV solution 500 mg (Zithromax, azithromycin, antibiotic)
Package details: 10 vials * 524.1 mg (equivalent to 500 mg azithromycin base)
Manufacturer: Pfizer Pharmaceuticals Inc., Ltd, Japan
Active ingredient: azithromycin dihydrate (chemical formula C38H76N2O14)
Medical effect: Zithromac powder for IV solution is effective for the treatment of community-acquired pneumonia and pelvic inflammatory diseases caused by susceptible organisms in patients who require initial IV therapy.
Contraindications and precautions: do not use for pregnant and breastfeeding women. Do not use for patients with liver or heart disease.
As this medicine may cause lack of concentration, patient should pay close attention when driving a car or operating dangerous mechanisms while taking this medicine.
The contents of the vial are under reduced pressure, which facilitates the injection of water for injection. In the unlikely event that the dissolving solution does not enter with normal operation, do not use it because there is a possibility that outside air has entered.
If an allergic reaction occurs, stop taking the medicine and consult with your doctor. If you’re taking any other medication, please consult with your doctor before use.
Dosage and administration
For adults: administer 500 mg (titer) of azithromycin once daily as an IV infusion over 2 hours. Dissolve the powder in 4.8 ml of water for injection (concentration: 100 mg/ml) and dilute it to an injection solution concentration of 1.0 mg/ml using an infusion solution that has been confirmed to have no compounding changes, such as 5% glucose injection. When preparing a 100 mg/ml solution, do not use any solution other than water. Before using this medicine, confirm that it has completely dissolved. Use immediately after reconstitution. After reconstitution and dilution, the recommended route of administration is by IV infusion only. Do not administer as an IV bolus or an intramuscular injection.
How effective is Zithromac powder for IV solution 500 mg from Japan (Zithromax, azithromycin, antibiotic)?
Zithromac powder contain azithromycin, a macrolide antibiotic that works by inhibiting bacterial protein synthesis. It is effective against some Gram-positive bacteria, some Gram-negative bacteria, and many atypical bacteria. Zithromac powder for IV solution is used for he treatment of patients who require initial IV therapy with community-acquired pneumonia or pelvic inflammatory diseases caused by following organisms:
- Chlamydia pneumoniae,
- Haemophilus influenzae,
- Legionella pneumophila,
- Moraxella catarrhalis,
- Mycoplasma pneumoniae,
- Staphylococcus aureus,
- Streptococcus pneumoniae,
- Chlamydia trachomatis,
- Neisseria gonorrhoeae,
- Mycoplasma hominis.
Who should take Zithromac powder for IV solution 500 mg from Japan?
Zithromac powder is designed for the patients who need urgent IV therapy with anitibiotics. The maximum duration of the course of treatment is 5 days, and the medicine should be used only to treat infections that are proven or strongly suspected to be caused by susceptible bacteria. Studies showed that clinical and bacteriologic response rates and the adverse event profile of intravenous azithromycin are similar to or better than comparative agents, and its unique pharmacokinetics and high and sustained tissue penetration allow for once-daily dosing with monotherapy (K. W. Garey, G. W. Amsden. “Intravenous azithromycin” // Annals of Pharmacotherapy, 1999, 33(2): 218-28).