Stalevo combination tablets 50 mg for Parkinson's disease and parkinsonian syndrome (levodopa, carbidopa, entacapone)
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General information on Japanese Stalevo combination tablets 50 mg for Parkinson's disease and parkinsonian syndrome (levodopa, carbidopa, entacapone)
Package details: 100 tablets
Manufacturer: Novartis Pharma K.K., Japan
- levodopa (chemical formula C9H11NO4),
- carbidopa hydrate (chemical formula C10H16N2O5),
- entacapone (chemical formula C14H15N3O5)
Medical effect: Stalevo combination tablets are effective for the treatment of Parkinson's disease and parkinsonian syndrome.
Contraindications and precautions: do not use for pregnant and breastfeeding women. Do not use for patients with glaucoma, patients with malignant syndrome or rhabdomyolysis or a history of those.
As this medicine may cause sudden sleepiness or decline of concentration, avoid driving a car, working at heights or operating dangerous mechanisms after taking this medicine.
This medicine may change the color of the liquids in your body (sweat, urine, saliva, phlegm or oral cavity can turn reddish brown or black). If that happen, consult with your doctor, especially if it's accompanied by pain.
If any compulsive symptoms (gambling, unplanned shopping, increases in sexual desire or appetite) occur or the patient desires more medicine than it was prescribed, the patient or their family should consult the doctor in charge.
If an allergic reaction occurs, stop taking the medicine and consult with your doctor. If you’re taking any other medication, please consult with your doctor before use.
Dosage and administration
For adults: take 1-2 tablets at a time. The doctor in charge may adjust the dosage or frequency of doses according to the symptoms. However, the daily dose should not exceed 1,500 mg as levodopa, 150 mg as carbidopa and 1,600 mg as entacapone. The frequency of doses may be increased up to 8 times a day.
Please note that this preparation contains 50 mg of levodopa in 1 tablet.
How effective are Stalevo combination tablets 50 mg from Japan for Parkinson's disease and parkinsonian syndrome (levodopa, carbidopa, entacapone)?
Stalevo combination tablets have three activeingredients: levodopa, carbidopa and entacapone. Levodopa is one of the most used and effective medicines for the treatment of Parkinson's disease. It is taken up into the brain, changes into dopamine and supplements insufficient dopamine. Carbidopa and entacapone help to inhibit metabolic enzyme of levodopa in the periphery and by thus, to increase the efficacy transfer of levodopa to the brain.
Who should take Stalevo combination tablets 250 mg from Japan?
Stalevo combination tablets are effective for the treatment of Parkinson's disease and parkinsonian syndrome. They help to improve daily variations in the symptoms of Parkinson's disease such as wearing-off phenomenon. Studies showed that levodopa and carbidopa combination also improves non-motor symptoms, such as sleep, fatigue, mood, cognition, gastrointestinal tract or urinary symptoms (R. Kruger, P. Lingor et al. “An Observational Study of the Effect of Levodopa–Carbidopa Intestinal Gel on Activities of Daily Living and Quality of Life in Advanced Parkinson’s Disease Patients”. Advances in Therapy, 2017; 34(7): 1741–1752).