Pirenzepine Hydrochloride tablets 25 mg (Gastrozepin) for gastritis and ulcer

General information on Japanese Pirenzepine Hydrochloride tablets 25 mg for gastritis and ulcer (Gastrozepin) 

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Package details: 100 tablets

Manufacturer: Nichi-iko Pharmaceutical Co. Ltd., Japan

Active ingredient: Pirenzepine hydrochloride hydrate (chemical formula C19H23Cl2N5O2)

Medical effect: Pirenzepine hydrochloride tablets are effective for the treatment of following diseases and conditions:

• gastric mucosal lesion (erosion, bleeding and flare, etc.),
• acute gastritis,
• acute exacerbation of chronic gastritis,
• gastrointestinal symptoms,
• gastric ulcer,
• duodenal ulcer.

Contraindications and precautions: do not use in pregnant, possibly pregnant or breastfeeding women. If an allergic reaction occurs, stop using the medication and consult with your doctor. If you’re taking any other medication, please consult with your doctor before use.

This medicine can cause sensitivity to light or other accommodation disturbances. Avoid driving a car or operating dangerous mechanisms while taking these medications.

Dosage and administration of Japanese Pirenzepine Hydrochloride tablets 25 mg for gastritis and ulcer (Gastrozepin)

For adults, take 1 tablet 3-4 times a day. The dosage may be adjusted according to the age or symptoms by the consulting doctor.

How effective are Pirenzepine Hydrochloride tablets 25 mg from Japan for gastritis and ulcer (Gastrozepin)?

Pirenzepine hydrochloride is a selective M1 selective muscarinic receptor antagonist. It works by blocking the muscarinic receptor of gastric parietal cells to suppress gastric acid secretion. At the same time, Pirenzepine Hydrochloride tablets increase the amount of gastric mucus and promote the defense function against gastric acid. As the result, this medicine effectively improves gastric erosion and bleeding in acute gastritis and acute exacerbation of chronic gastritis and treats gastric ulcer and duodenal ulcer.

Who should use Pirenzepine Hydrochloride tablets 25 mg from Japan?

Studies showed that unlike other muscarinic receptor antagonists like atropine, pirenzepine has a lesser effect on salivary flow and virtually no effect on heart rate or gut motility (M. Feldman. Inhibition of gastric acid secretion by selective and nonselective anticholinergics // Gastroenterology.1984, 86, 361-366). That’s why it can be used for patients with heart diseases. Also, Pirenzepine Hydrochloride tablets have no effects on the brain and spinal cord as the active substance cannot diffuse through the blood–brain barrier.