Nocbin powder 25 g for chronic alcoholism

General information on Japanese Nocbin powder 25 g for chronic alcoholism 

Package details: 25 g

Manufacturer: Mitsubishi Tanabe Pharma Corporation, Japan

Active ingredient: disulfiram (chemical formula C10H20N2S4)

Medical effect: Nocbin powder inhibits the enzyme acetaldehyde dehydrogenase and causes an acute sensitivity to ethanol, including headache, nausea, vomiting etc. It is effective support the treatment of chronic alcoholism.

Contraindications and precautions: do not use in the following categories of patients:

• patients with cardiac disorders,
• patients with liver disorders or renal disorders,
• patients with respiratory diseases,
• pregnant or breastfeeding women.

Dosage and administration of Japanese Nocbin powder 100 g for chronic alcoholism 

Take 0.1 to 0.5 g a day, in 1 to 3 divided doses. After getting stabilized, the consulting doctor may decrease a dosage into 0.1 to 0.2 g a day and to change the schedule from everyday intake to 1-week administration period and 1-week cessation period.

Do not drive a car or operate dangerous machinery while taking this medicine.

Do not take alcohol unless your doctor instructs you to do so. This includes taking any food containing alcohol such as chocolate with liquor, drinking medicines containing alcohol such as medicated liquor, or using cosmetics such as after-shaving lotion.

How effective is Nocbin powder 25 g from Japan for chronic alcoholism?

Nocbin powder is effective for anti-alcohol therapy for chronic alcoholism as it motivates patients not to take alcohol by inducing unpleasant symptoms such as nausea, vomiting etc. It works by inhibiting a certain enzyme and suppressing metabolism of acetaldehyde mainly produced by metabolism of alcohol in the liver. Studies show that disulfiram is a safe and efficacious treatment compared to other abstinence supportive pharmacological treatments (M. D. Skinner, P. Lahmek et al. Disulfiram Efficacy in the Treatment of Alcohol Dependence: A Meta-Analysis. PLOS One, 2014; 9(2). https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087366 ).

Who should use Nocbin powder 25 g for chronic alcoholism?

Japanese powder Nocbin 100 g for chronic alcoholism is used in the treatment of alcohol dependence with consistently successful results in patients with high compliance or when medication intake is directly supervised by the consulting doctors or caregivers. It performs primarily psychological action for maintaining alcohol abstinence. By causing strong unpleasant symptoms immediately after alcohol intake, Nocbin powder motivates the patient to avoid taking alcohol. Also, there are some evidences that disulfiram inhibits dopamine beta-hydroxylase (DBH) and reduces pleasant feeling after taking alcohol.