Mycophenolate Mofetil Capsules TEVA 250 mg for suppressing immune response

General information on Japanese Mycophenolate Mofetil Capsules TEVA 250 mg for suppressing immune response    

Package details: 100 capsules

Manufacturer: Teva Takeda Pharma Ltd., Japan

Active ingredient: mycophenolate mofetil (chemical formula C23H31NO7)

Medical effect: TEVA Mycophenolate Mofetil capsules are effective for the following purposes:

• inhibiting activity and growth of lymphocytes,
• treating refractory rejection after renal transplantation,
• suppressing rejection of renal, heart, liver, lung, pancreas transplantation,
• treating lupus nephritis.

Contraindications and precautions: do not use in patients with digestive system disorder, chronic renal failure, slow recovery for renal function after renal transplantation. Do not use in pregnant or breastfeeding women. If an allergic reaction occurs, stop using the medication and consult with your doctor. If you’re taking any other medication, please consult with your doctor before use.

Both male and female patients must avoid pregnancy and use birth control before, during this medicine and for 6 weeks after finishing this medicine because it may cause fetal malformation. Patient must wear protective clothes and effective sunscreen to avoid sunlight or ultraviolet rays while taking this medication.

Dosage and administration of Japanese Mycophenolate Mofetil Capsules TEVA 250 mg for suppressing immune response

1. For refractory rejection after renal transplantation: for adults, 6 capsules 2 times a day, every 12 hours after meals.
2. For rejection of renal transplantation: 4 capsules 2 times a day, every 12 hours after meals. The dosage may be increased up to 12 capsules per day. For children, take 300 to 600 mg/m2 of the active ingredient at a time, 2 times a day, every 12 hours after meals. The dosage may be increased up to 8 capsules per day.
3. For rejection of heart/liver/lung/pancreas transplantation: For adults, 2-6 capsules 2 times a day, every 12 hours after meals.
4. For lupus nephritis: for adults, 1-4 capsules 2 times a day, every 12 hours after meals. The dosage may be increased up to 12 capsules per day. For children, take 150 to 600mg/m2 of the active ingredient at a time, 2 times a day, every 12 hours after meals. The dosage may be increased up to 8 capsules per day.

If patient has a severe chronic renal failure, the maximum dosage is 4 capsules 2 times a day.

The dosage may be adjusted by the consulting doctor due to age and symptoms.

How effective are Mycophenolate Mofetil Capsules TEVA 250 mg from Japan for suppressing immune response?

TEVA capsules contain the mofetil of mycophenolic acid, an immunosuppressive medication that works by blocking inosine monophosphate dehydrogenase (IMPDH) and, by this, blocking lymphocytes from making guanosine. TEVA capsules are effective for the prevention of organ transplant rejection, for treating refractory rejection when the patient does not response to the existing medicines and for treating autoimmune diseases.

Who should use Mycophenolate Mofetil Capsules TEVA 250 mg from Japan?

Three large-scale clinical trials showed that mycophenolate mofetil significantly reduces the risk of acute rejection after the organ transplantation (G. Ciancio, J. Miller, T. A. Gonwa. Review of Major Clinical Trials With Mycophenolate Mofetil in Renal Transplantation // Transplantation, 2005, October, 15: 80 (2 Suppl.), 191-200). Currently, TEVA capsules are prescribed for suppressing the rejection of renal, heart, liver, lung and pancreas transplantation. The capsules can be used for both adults and children, the dosage should be constantly monitored by the consulting doctor. Also, Mycophenolate Mofetil Capsules TEVA 250 mg can be used for treating autoimmune diseases and similar immune-mediated disorders including Behçet's disease, pemphigus vulgaris, immunoglobulin A nephropathy, small vessel vasculitides, and psoriasis. The medicine shows the more frequent complete response in treating lupus nephritis.