Methylene blue intravenous injections 50 mg for toxic methemoglobinemia (Methylthioninium chloride, Provayblue, Proveblue)

General information on Japanese Methylene blue intravenous injections 50 mg for toxic methemoglobinemia (Methylthioninium chloride, Provayblue, Proveblue)

Package details: 1 ampoule * 10 ml

Manufacturer: Daiichi Sankyo Co., Ltd., Japan

Active ingredients: methylthioninium chloride hydrate (chemical formula C9H15ClO2S)

Medical effect: Methylene blue injections are effective for the treatment of toxic methemoglobinemia.

Contraindications and precautions: do not use for the following categories of patients:

• Patients with glucose-6-phosphate dehydrogenase deficiency or NADPH reductase deficiency cannot use Methylene blue intravenous injections,
• Patients with methemoglobinemia with chlorate,
• Patients with methemoglobinemia due to nitrite used as antidote for cyanide poisoning,
• Pregnant or breastfeeding women,
• Patients with renal dysfunction,
• Patients with methemoglobinemia with aniline or diaphenylsulfone.

Blood oxygen saturation may show an apparently low value when measured by pulse oximeter while taking this medicine.

If an allergic reaction occurs, stop using the medicine and consult with your doctor. If you’re taking any other medication or receiving any other treatment, you have to consult with your doctor before use.

Dosage and administration

Inject this medicine intravenously. If symptoms do not improve within 1 hour after injection, repeat injection as needed. The treatment should be performed under the strict monitoring of the consulting doctor.

How effective are Methylene blue intravenous injections 50 mg from Japan for toxic methemoglobinemia (Methylthioninium chloride, Provayblue, Proveblue)?

Methylene blue intravenous injections contain methylthioninium chloride hydrate, a thiazine dye used in medicine. It works by changing to leucomethylene blue in red blood cells and reducing methemoglobin back to hemoglobin. As the result, Methylene blue intravenous injections can rapidly improve methemoglobinemia.

Who should use Methylene blue intravenous injections 50 mg from Japan?

Methylene blue intravenous injections are prescribed for patients with toxic methemoglobinemia. Particularly, researchers recommend to use it in case when methemoglobin levels are greater than 30% an asymptomatic patient and 20% in a symptomatic patient (H. U. Rehman. “Methemoglobinemia. Evidence-based case review”. WJM, 2001 Sep; 175(3): 193–196)