Jadenu granules sachet 360 mg for chronic iron overload (Deferasirox, Exjade, Asunra, Oleptiss)
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General information on Japanese Jadenu granules sachet 360 mg for chronic iron overload (Deferasirox, Exjade, Asunra, Oleptiss)
Package details: 30 bags
Manufacturer: Novartis Pharma K.K., Japan
Active ingredients: deferasirox (chemical formula C21H15N3O4)
Medical effect: Jadenu granules are effective for the treatment of chronic iron overload due to blood transfusions.
Contraindications and precautions: do not use for the following categories of patients:
- Patients with blood platelet count is less than 50,000/mm3 cannot use Jadenu granules,
- Patients with myelodysplastic syndrome,
- Patients with malignancy,
- Pregnant or breastfeeding women,
- Patients with renal or liver disorder.
As this medicine may cause dizziness, visual or hearing impairment, patients should take care when driving a car or operating dangerous machinery after administering this medicine.
If this medicine is taken together with 500 mg or more vitamin C orally, the combination may cause the deterioration of cardiac function. Patients should consult with their doctor or pharmacist when taking any medicines or supplements including vitamin C.
If an allergic reaction occurs, stop using the medicine and consult with your doctor. If you’re taking any other medication or receiving any other treatment, you have to consult with your doctor before use.
Dosage and administration
Take 12 mg of the active ingredient per kg of body weight at a time, once a day. The doctor in charge should adjust the dosage according to patient’s needs. However, the maximum dosage of 18 mg/kg per day should not be exceeded.
Please note that 1 package of this medicines contains 360 mg of the active ingredient. It may be used with packages which have same active ingredient but have different content (90 mg).
How effective are Jadenu granules sachet 360 mg from Japan for chronic iron overload (Deferasirox, Exjade, Asunra, Oleptiss)?
Jadenu granules contain deferasirox, an oral iron chelator. It works by binding and excreting excessively accumulated iron from the body. Deferasirox removes the excessive iron not only from the blood, but also from the cells, such as cardiac myocytes and hepatocytes.
Who should use Jadenu granules sachet 360 mg from Japan?
Jadenu granules are effective for the treatment of chronic iron overload due to blood transfusions for conditions such as beta-thalassemia and other chronic anemias. This medicine is particularly recommended for use in case the treatment with iron chelator injection is inadequate. Due to low molecular weight and high lipophilicity of deferasirox, it can be taken orally unlike other chelators like deferoxamine (C. Bollig, L. K. Schell et al. “Deferasirox for managing iron overload in people with thalassaemia”. Cochrane database of systematic reviews, 2017, 8(8): CD007476).