Escre rectal kit 500 mg for sedation and hypnosis (chloral hydrate)

General information on Japanese Escre rectal kit 500 mg for sedation and hypnosis (chloral hydrate)

Package details: 10 kits

Manufacturer: Hisamitsu Pharmaceutical Co., Inc., Japan

Active ingredient: chloral hydrate (chemical formula C2H3Cl3O2)

Medical effect: Escre rectal kit is effective for sedation and hypnosis at laboratory tests (such as electroencephalography, electrocardiography and electromyography) and for treatment of convulsion difficult for treatment with intravenous injection.

Contraindications and precautions: do not use for pregnant and breastfeeding women. Do not use for patients with acute intermittent porphyria.

If an allergic reaction occurs, stop using the medicine and consult with your doctor. If you’re taking any other medication, please consult with your doctor before use.

Dosage and administration

For children: inject 30-50 mg of the active ingredient per kg of the body weight into rectum at a time. The doctor in charge may adjust the dosage according to the age, symptoms or purpose. However, the maximum total dose of 1.5 g at a time should not be exceeded. Please note that this medicine contains 500 mg of the active ingredient in a kit.

How effective is Escre rectal kit 500 mg from Japan for sedation and hypnosis (chloral hydrate)?

Escre rectal kits contain chloral hydrate, a geminal diol produced from chlorine and ethanol in acidic solution. It works by enhancing the GABA receptor complex, decreasing the excitability of neurons and subsequently reducing the communication between neurons. As the result, Escre rectal kits provide calming effect on many of the functions of the brain and anticonvulsive effect.

Who should use Escre rectal kit 500 mg from Japan?

Escre rectal kits are used for sedation and hypnosis at laboratory tests (such as electroencephalography, electrocardiography and electromyography), especially for pediatric patients, and for treatment of convulsion difficult for treatment with intravenous injection. Studies involving more than 2000 children undergoing neurodiagnostic procedures in hospitals showed that chloral hydrate is relatively safe and has a low sedation failure rate when a child needs to remain still for 30-45 minutes in order to get diagnostics (Choong Yi Fong, Chee Geap Tay et al. “Chloral hydrate as a sedating agent for neurodiagnostic procedures in children”. Cochrane Database of Systematic Reviews, 2017, 11(11): CD011786).