Deberza tablets 20 mg for type 2 diabetes (tofogliflozin hydrate, CSG452, Apleway)
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General information on Japanese Deberza tablets 20 mg from Japan for type 2 diabetes (tofogliflozin hydrate, CSG452, Apleway)
Package details: 100 tablets
Manufacturer: Kowa Co., Ltd., Japan
Active ingredients: tofogliflozin hydrate (chemical formula C22H28O7)
Medical effect: Deberza tablets are effective for the treatment of type 2 diabetes mellitus.
Contraindications and precautions: do not use for the following categories of patients:
- pregnant or breastfeeding women,
- patients with ketosis, diabetic coma or precoma,
- patients with infection or injury,
- patients in the pre-/post-operative period.
As this medicine may cause hypoglycemia, patient should take care when working at heights, operating dangerous machinery or driving a car.
If hypoglycemic symptoms occur while patient is taking this medicine concomitantly with an alpha-glucosidase inhibitor (acarbose, voglibose, etc.), patient should take the glucose. It’s recommended to carry sugar or glucose to use in case of hypoglycemia and to carry a card of diabetic patient.
In some rare cases this medicine may cause urinary-tract infection or genital infection. Patient should pay attention to the unusual symptoms and consult with the doctor if needed.
As this medicine may cause frequent urination, patients should drink an adequate amount of fluid and pay attention to excessive decrease in body weight.
If an allergic reaction occurs, stop using the medicine and consult with your doctor. If you’re taking any other medication or receiving any other treatment, you have to consult with your doctor before use.
Dosage and administration
For adults: take 1 tablet (20 mg of active ingredient) once a day, before or after breakfast.
How effective are Deberza tablets 20 mg from Japan for type 2 diabetes (tofogliflozin hydrate, CSG452, Apleway)?
Deberza tablets contain tofogliflozin hydrate, a highly specific sodium/glucose cotransporter inhibitor. It works by inhibiting high glucose-induced reactive oxygen species generation in tubular cells and consequently inhibiting glucose reabsorption in kidneys. By this, Deberza tablets promote the excretion of glucose into urine and decrease the blood sugar level.
Who should use Deberza tablets 20 mg from Japan?
Deberza tablets are effective for the treatment of type 2 diabetes mellitus. Studies showed that the course of treatment with tofogliflozin for the 52 weeks was safe for patients, generally well-tolerated, and effective both when used solely or together with other antidiabetic medicines like acarbose or voglibose (Y. Tanizawa, K. Kaku et al. Long-term safety and efficacy of tofogliflozin, a selective inhibitor of sodium-glucose cotransporter 2, as monotherapy or in combination with other oral antidiabetic agents in Japanese patients with type 2 diabetes mellitus: multicenter, open-label, randomized controlled trials // Expert opinion on pharmacotherapy. 2014, 15(6): 749-66).