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New Year Holidays 2025 / 2026
11/12/2025
Dear Customers,
Please pay attention to work schedule and shipping delays during local New Year holidays in Japan.
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Coralan tablets 5 mg for chronic heart failure (ivabradine hydrochloride)
Product Code :
Availability : 5
USD 449.00
Are Coralan tablets 5 mg effective for chronic heart failure (ivabradine hydrochloride)?
Managing chronic heart failure treatment effectively requires innovative solutions that improve heart function while minimizing side effects. Coralan tablets, formulated with ivabradine hydrochloride, provide a targeted approach to reducing heart rate without compromising cardiac contractility. As a result, they play a crucial role in enhancing cardiovascular efficiency and improving patient outcomes for individuals suffering from chronic heart failure and angina treatment.
Coralan’s active ingredient, ivabradine hydrochloride, is a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker. It works by selectively inhibiting the If current in the sinoatrial node, effectively slowing heart rate without the negative inotropic effects associated with beta-blockers and calcium channel blockers. This mechanism reduces myocardial oxygen demand, allowing the heart to function more efficiently. Additionally, it improves blood flow to the myocardium, enhancing oxygen supply to heart tissues. Unlike traditional angina tablets, Coralan provides a selective effect on heart rate without affecting blood pressure or contractility, making it a well-tolerated choice for patients with heart conditions.
Clinical Effectiveness and Safety
Numerous studies have demonstrated the efficacy and safety of ivabradine tablets in patients with chronic heart failure treatment. A Japanese study, titled “The efficacy and safety of ivabradine hydrochloride in hemodialysis patients with chronic heart failure,” highlighted significant benefits:
- A decrease in heart rate, from an average of 87 beats per minute (bpm) to 75.85 bpm over time.
- Stabilized systolic blood pressure, leading to improved cardiovascular function.
- Reduced frequency of dialysis-related hypotension, ensuring safer treatment for patients undergoing hemodialysis.
- No serious adverse events, confirming the favorable safety profile of ivabradine.
Benefits of Coralan Tablets for Angina and Heart Failure Patients
Patients suffering from chronic heart failure and angina treatment can benefit from Coralan in multiple ways:
- Targeted heart rate reduction, improving cardiac efficiency without affecting contractility.
- Fewer side effects, unlike beta-blockers and calcium channel blockers.
- Enhanced quality of life, with better exercise tolerance and reduced symptoms of angina.
- Safe for patients with contraindications to beta-blockers, offering an alternative for those who cannot tolerate traditional therapies.
For individuals seeking an effective chronic heart failure treatment, Coralan tablets provide a clinically proven solution that reduces heart rate while preserving cardiac function. With ivabradine tablets, patients experience better heart health, reduced angina symptoms, and improved overall well-being. Consult your healthcare provider to determine if Coralan is the right angina treatment for your condition.
Package details: 100 tablets
Dosage and administration: adults should start with taking 0.5 tablets (2.5 mg of ivabradine) at a time 2 times a day after meals. When increasing or decreasing the dosage, it should be done gradually, with an interval of at least 2 weeks, according to the heart rate at rest and tolerability. A standard dosage is either 0.5 tablets. 1 tablet or 1.5 tablets (2.5, 5 or 7.5 mg of active ingredient), twice a day after meals. Your doctor may adjust the dosage according to your conditions. Please note that this medicine contains 5 mg of ivabradine in a tablet.
Active components: ivabradine hydrochloride
Therapeutic effect: improving chronic heart failure with sinus rhythm and heart rate at rest of over 75 beats per minute at the start of treatment course
Contraindications and precautions: Store in a dry cool place, out of reach of children. Do not use for pregnant, possibly pregnant or breastfeeding women. Do not use for patients with unstable/acute heart failure, cardiogenic shock, hypotension, sick sinus syndrome, sinoatrial block/third-degree atrioventricular block (excluding patients with a pacemaker), patients with liver dysfunction (Child-Pugh C), patients with tachycardiac arrhythmia (ventricular or supraventricular), first-degree and second-degree atrioventricular block, ventricular conduction disorder (bundle branch block) or ventricular dyssynchrony.
If you accidentally exceed your prescribed dose, you may experience bradycardia, which can cause symptoms such as dizziness, lightheadedness when standing up, shortness of breath, a slow pulse, irregular heartbeats, or fainting. If multiple symptoms occur simultaneously, stop taking the medication and consult with health care professionals immediately. Female patients who may become pregnant should avoid pregnancy while taking this medication and for a specified period after completing the treatment. Use with caution when operating hazardous machinery, including driving, as this medication may cause symptoms such as sudden flashes of light in the dark, blurry vision, dizziness, and lightheadedness. If you experience any of these symptoms, strictly avoid driving or operating dangerous machinery. Avoid taking this medication with St. John’s Wort or grapefruit juice, as these substances may alter its effectiveness by either reducing or enhancing its medicinal effects.
Do not expose to sunlight or heat. If allergic symptoms occur, discontinue use.
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News
New Year Holidays 2025 / 2026
11/12/2025
Dear Customers,
Please pay attention to work schedule and shipping delays during local New Year holidays in Japan.
We stop accepting orders this year: December 25th . Please check shipping estimates on order confirmation before you pay.
We resume accepting orders next year January 7th
We stop all operations (shipping, email support) from December 27th, we shall ship all items that shall arrive by December 26th.
We resume shipping after January 7th, please wait for notifications,
Our website shall send auto-reply during holiday period. Please do not send multiple emails as there is small possibility that we may overlook them. We shall reply after the holidays, we may need 1-2 days to reply if the amount of eamils is big. Please wait.
Please pay attention to possible delays in shipping - some specific items ordered after December 10th may be only shipped after holidays. If you are in a hurry, please inquiry on shipping estimates before you pay.
There are also delays in transit that already began and shall last at least till Mid-January.
Thank you and we look forward to serving you next year. We also wish you a wonderful Holiday Season.
Sincerely yours
JHC