Ciclosporine capsules 10 mg for autoimmune diseases and transplantation (cyclosporine, cyclosporin, ciclosporin, Neoral, Sandimmune)

General information on Japanese Ciclosporine capsules 10 mg for autoimmune diseases and transplantation (cyclosporine, cyclosporin, ciclosporin, Neoral, Sandimmune)

Package details: 100 capsules

Manufacturer: BioMedix Co., Ltd. / Nichi-Iko Pharmaceutical Co., Ltd. / Towa Pharmaceutical Co., Ltd., Japan

Active ingredients: ciclosporin (chemical formula C62H111N11O12)

Medical effect: Ciclosporine capsules are effective for the treatment of following:

• rejection of organ transplantation (kidney, liver, heart, lung, pancreas, small intestine),
• rejection and/or graft-versus-host disease caused by bone-marrow transplantation,
• Behcet's disease with symptoms in eye,
• non-infectious uveitis,
• psoriasis,
• aplastic anemia,
• pure red-cell aplasia,
• nephrotic syndrome,
• myasthenia gravis,
• atopic dermatitis.

Contraindications and precautions: do not use for pregnant, possibly pregnant or breastfeeding women. Do not use for patients with neural Behcet's disease, renal disorder, liver disorder or infection. Do not use for patients with malignant tumor or a history of it.

If an allergic reaction occurs, stop using the medicine and consult with your doctor. If you’re taking any other medication or receiving any other treatment, you have to consult with your doctor before use.

As this medicine causes immune suppression, the patient may become susceptible to infection. Patient should try to avoid the infections by avoiding crowded places, frequently washing hands, gargling etc. A vaccination may be received only with the permission of doctor in charge.

Avoid taking grapefruit juice and any food or supplements containing St. John's wort while taking this medicine.

Dosage and administration

For psoriasis: take 2.5 mg/kg of the active ingredient at a time, 2 times a day. When the effect appears, the dosage should be gradually decreased by 1 mg/kg a day, every additional month. The standard maintenance dosage is 3 mg/kg a day.

For aplastic anemia, pure red cell aplasia: take 3 mg/kg of the active ingredient at a time, 2 times a day.

For systemic myasthenia gravis: take 2.5 mg/kg of the active ingredient at a time, 2 times a day. When the effect appears, the dosage should be gradually decreased. The standard maintenance dosage is 3 mg/kg a day.

For atopic dermatitis: for adults, take 1.5 mg/kg of the active ingredient at a time, 2 times a day. The dosage may be adjusted according to symptoms of the patient, but the maximum daily dose of 5 mg/kg should not be exceeded.

For other indications: please consult with your doctor in charge.

How effective are Ciclosporine capsules 10 mg from Japan for autoimmune diseases and transplantation (cyclosporine, cyclosporin, ciclosporin, Neoral, Sandimmune)?

Ciclosporin is a calcineurin inhibitor and an immunosuppressant. It works by suppressing the activation of helper T cells through lymphocyte-specific/reversible immunosuppressive effects and, as the result, suppressing abnormal immune reactions. Ciclosporine capsules can be used used to suppress rejection after organ transplantation (kidney, liver, heart, lung, pancreas, small intestine) and rejection or graft-versus-host disease after bone marrow transplantation.

Who should use Ciclosporine capsules 10 mg from Japan?

Ciclosporine capsules are effective for the treatment of various autoimmune diseases, including Behcet's disease with symptoms in eye, non-infectious uveitis, psoriasis, aplastic anemia, pure red-cell aplasia, nephrotic syndrome, myasthenia gravis and atopic dermatitis. Studies showed that with regular monitoring of the patient’s condition and using the lowest individually titrated effective dose cyclosporine is an effective and safe therapy for selected autoimmune diseases even in long-term treatment (G. Feutren. “The optimal use of cyclosporin A in autoimmune diseases”. Journal of Autoimmunity, 1992, 5 Suppl. A: 183-95)