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03/12/2024
Please pay attention that due to local holidays in Japan (End of Year holidays – Dec 27th to Jan 5th) we shall operate as follows:
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Cholebine tablets 500 mg for hypercholesterolemia and familial hypercholesterolemia (colestimide, colestilan, BindRen)
Cholebine tablets 500 mg for hypercholesterolemia and familial hypercholesterolemia (colestimide, colestilan, BindRen)
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Availability : 10
USD 69.00
General information on Japanese Cholebine tablets 500 mg for hypercholesterolemia and familial hypercholesterolemia (colestimide, colestilan, BindRen)
Package details: 100 tablets
Manufacturer: Mitsubishi Tanabe Pharma Corporation, Japan
Active ingredient: colestemide
Medical effect: Cholebine tablets are effective for the treatment of hypercholesterolemia and familial hypercholesterolemia
Contraindications and precautions: do not use for pregnant and breastfeeding women. Do not use for patients with complete biliary obstruction or intestinal obstruction.
Try to swallow this medicine as promptly as possible. If you couldn't promptly swallow the tablet and it remained in your mouth or back of the throat, drink more water.
Don't take this medicine with warm water, use water of a room temperature or cold water.
If an allergic reaction occurs, stop taking the medicine and consult with your doctor. If you’re taking any other medication, please consult with your doctor before use.
Dosage and administration
Adults should take 3 tablets (1.5 g of the active principle) at a time, 2 times a day, before breakfast and dinner. Your doctor may also prescribe to take this medicine after breakfast and dinner depending on your symptoms or dosing condition. Your doctor may adjust the dosage according to your disease, age and symptoms. However, the maximum daily dose of 8 tablets (4 g) should not be exceeded.
How effective are Cholebine tablets from Japan hypercholesterolemia and familial hypercholesterolemia (colestimide, colestilan, BindRen)?
Cholebine tablets, containing the active component colestimide, are frequently prescribed for the treatment of hypercholesterolemia and familial hypercholesterolemia. This medication operates by utilizing its capacity to bind bile acids, effectively reducing serum cholesterol levels. The primary mechanism of action of Cholebine tablets centers on their ability to adsorb bile acids and cholesterol within the digestive tract. Colestimide serves as a bile acid sequestrant, functioning by attaching to bile acids in the intestinal lumen. Through the formation of non-absorbable complexes with bile acids, Cholebine hinders their reabsorption and promotes their elimination through feces. This triggers the liver to increase the utilization of cholesterol for the synthesis of new bile acids, consequently reducing the overall cholesterol content in the bloodstream.
Who should take Cholebine tablets from Japan?
Cholebine's efficiency in lowering cholesterol levels is well-established. By intercepting bile acids, it disrupts the enterohepatic circulation of these compounds, compelling the liver to rely on cholesterol reserves for generating more bile acids. As a result, this depletes the cholesterol supply within the liver and leads to the upregulation of low-density lipoprotein (LDL) receptors on hepatocytes. This heightened expression of LDL receptors on liver cells further contributes to the removal of LDL cholesterol from the bloodstream. In the context of familial hypercholesterolemia, a genetic disorder characterized by elevated LDL cholesterol levels, Cholebine tablets offer a localized method of intervention, making them a valuable complement to other lipid-lowering treatments. Cholebine tablets may also be used in combination with other medications.
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New Year Holidays 2024 / 2025
03/12/2024
Please pay attention that due to local holidays in Japan (End of Year holidays – Dec 27th to Jan 5th) we shall operate as follows:
ORDER ACCEPTANCE
We stop accepting orders during holidays from Dec 26th to Jan 3rd. Website will not allow orders, please order on Jan 3rd, evening (Japanese time)
No suppliers will operate this week so changes in shipping time / price / product availability are possible. Product may become unavailable as well.
Please pay attention: orders paid after Dec 15th may be shipped after Jan 6th because Japan Post and courier services will not operate during Holidays. If you pay before we are 99% likely to ship before holidays. If you pay after make sure you can wait as delays are possible due to end of year holidays. Some suppliers stop working before Dec 26th, please pay attention!
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We shall resume support work on Jan 3rd, but we may need time to reply.
We shall continue to work as usual starting Jan 6th.
Pay attention that payments may be affected by your local holidays in your country / country of payment systems (during Christmas holidays and New Year holidays).
SHIPIPNG - DELAYS till January 10th.
We stop shipping all orders from Dec 28th to Jan 6th. Japan Post and courtier services will not work during this period so there are possible delays for some orders (mainly injections and some tablets) paid after Dec 15th
We shall resume normal work from Monday 6th.