Spironolactone tablets 50 mg for edema and hypertension (Aldactone, Spiractin, Verospiron)

General information on Japanese Spironolactone tablets 50 mg for edema and hypertension (Aldactone, Spiractin, Verospiron)

Package details: 100 tablets

Manufacturer: Yoshindo Inc., Japan

Active ingredients: spironolactone (chemical formula C24H32O4S)

Medical effect: Spironolactone tablets are effective for the treatment of following diseases and conditions:

• hypertension,
• cardiac edema (congestive heart failure),
• renal or hepatic edema,
• idiopathic edema,
• edema and ascites associated with malignant tumors,
• malnutrition edema,
• primary aldosteronism (for diagnosis and improving symptoms).

Contraindications and precautions: do not use patients with anuria or acute renal failure, hyperkalemia, Addison disease, cardiac disease, coronary or cerebral arterial sclerosis, renal disorder or liver disorder. Do not use for patients on low-salt diet. Do not use for pregnant or breastfeeding women.

As this medicine may cause dizziness, take care when operating dangerous machinery, working at heights or driving a car while taking this medicine.

Avoid taking this medicine after supper as it may cause more frequent urination.

If an allergic reaction occurs, stop using the medicine and consult with your doctor. If you’re taking any other medication or receiving any other treatment, you have to consult with your doctor before use.

Dosage and administration

For adults: take 1-2 tablets (50-100 mg of the active ingredient), dividing in 2 doses if needed. The doctor in charge may adjust the dosage according to the disease, age or symptoms.

How effective are Spironolactone tablets from Japan for edema and hypertension (Aldactone, Spiractin, Verospiron)?

Spironolactone is a derivative of progesterone and a potent antimineralocorticoid. It works by inhibiting the action of aldosterone, a steroid hormone produced by adrenal gland and essential for sodium conservation in the body. By this, Spironolactone tablets increase urinary volume, remove swelling of the body by excreting excess water, and consequently lower the blood pressure.

Who should use Spironolactone tablets from Japan?

Spironolactone tablets are effective for the treatment of hypertension, cardiac edema (congestive heart failure), renal edema, hepatic edema, idiopathic edema, edema and ascites associated with malignant tumors and malnutrition edema. Also, this medicine is used to diagnose primary aldosteronism and to improve its symptoms. Studies showed that spironolactone decreases the risk of death in patients with heart failure history for 30%, also decreasing the risk of hospitalization and improving overall symptoms (B. Pitt, F. Zannad et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure // The New England journal of medicine. 1999, 341(10): 709-17). Moreover, Spironolactone tablets may be used as a component of feminizing hormone therapy in transgender women upon the decision of doctor in charge.