Japanese immunomodulators: how to choose?

Japanese immunomodulators: how to choose?

Japanese market can offer a lot of different immunomodulators. It’s easy to get lost in their number. Which of them are effective? And how to choose the immunomodulator from Japan that suits your particular needs? Let’s check it out.

Arabinoxylan

Arabinoxylan is a hemicellulose consisting of two pentose sugars, arabinose and xylose. It can be found in the cell walls of some plants. Studies show that this plant-based immunomodulator is effective in a conventional therapy in treating cancer (along with chemotherapy and radiotherapy), hepatitis C virus, human immunodeficiency virus (HIV) (Soo Liang Ooi, Debbie McMullen et al. “Evidence-Based Review of BioBran/MGN-3 Arabinoxylan Compound as a Complementary Therapy for Conventional Cancer Treatment” Integrative Cancer Therapies, 2018 Jun; 17(2): 165–178; Hosny Salama, Eman Medhat et al. “Arabinoxylan rice bran (Biobran) suppresses the viremia level in patients with chronic HCV infection: A randomized trial”. International Journal of Immunopathology and Pharmacology, 2016 Dec; 29(4): 647–653; Mamdooh Ghoneum and Magda Shaheen. “MRN-100, an Iron-based Compound, Possesses Anti-HIV Activity In Vitro”. Evidence-Based Complementary and Alternative Medicine, 2010 Dec; 7(4): 427–432). In our store you can order Japanese immunomodulators in different package and dosage:

• Biobran-250 40 tabs, containing 250 mg of arabinoxylan in each tablet,
• Lentin 30 sachets, containing 1000 mg in each sachet,
• Lentin 90 sachets, containing 1000 mg in each sachets.

Agaricus mushrooms

Agaricus is a genus of mushrooms in Agaricomycetes class. Multiple studies show that extracts of some species of Agaricus mushrooms have immunomodulatory and immunostimulatory effects along with anti-tumor activities (Cynthia H. Val, Fátima Brant et al. “Effect of mushroom Agaricus blazei on immune response and development of experimental cerebral malaria”. Malaria Journal, 2015; 14: 311. https://malariajournal.biomedcentral.com/articles/10.1186/s12936-015-0832-y ; Fhernanda R. Smiderle, Andrea C. Ruthes et al. “Polysaccharides from Agaricus bisporus and Agaricus brasiliensis show similarities in their structures and their immunomodulatory effects on human monocytic THP-1 cells”. BMC Complementary and Alternative Medicine, 2011; 11: 58. https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-11-58 ; Yanqing Zhang, Guijie Ma et al. “The Immunostimulatory and Anti-tumor Activities of Polysaccharide from Agaricus bisporus (brown)”. Journal of Food and Nutrition Research, 2014, Vol. 2, No. 3, 122-126). That’s why Japanese immunomodulators from Agaricus fungi are effective in conventional therapy in treating cancer and in treating inflammations. In our store you can order two types of Agaricus-based immunomodulators from Japan: Agaricus with beta-glucans containing 1280 mg of agaricus extract in a daily dose or King Agaricus containing 1125 mg of agaricus extract and 1125 mg of agaricus mycelium extract in a daily dose.

Other plant-based immunomodulators

Amongst other plant-based immunomodulators from Japan we shall bring Perilla extract. Perilla extract has showed antioxidant, antimicrobial, anti-allergic, antidepressant, anti-inflammatory, anticancer, and neuroprotection effects in multiple studies (In Hwa Jeon, Hyeon Soo Kim et al. “Anti-Inflammatory and Antipruritic Effects of Luteolin from Perilla (P. frutescens L.) Leaves”. Molecules. 2014 Jun; 19(6): 6941–6951; Ragazinskiene O., Gailys V. et al. “Common perilla (Perilla frutescens (L.) Britton.) as a perspective immunomodulator”. Medicina (Kaunas). 2004; 40(3): 220-4).

One more effective immunomodulator, Active Hexose Correlated Compound (AHCC), is found in the Shiitake mushrooms. Researches have found that AHCC from Shiitake mushrooms increases immune reactions and can be used as an effective immunomodulator (Judith A. Smith, Lata Mathew et al. “From Bench to Bedside: Evaluation of AHCC Supplementation to Modulate the Host Immunity to Clear High-Risk Human Papillomavirus Infections”. Frontiers in Oncology, 2019; 9: 173; Peter Amwoga Ayeka. “Potential of Mushroom Compounds as Immunomodulators in Cancer Immunotherapy: A Review”. Evidence-Based Complementary and Alternative Medicine, 2018: 7271509).

Also we should name Lipopolysaccharides (LPS), also known as lipoglycans and endotoxins. This substance possesses monocyte/macrophage activation ability and is used for immunotherapy in cancer (Maryam A. Shetab Boushehri, Mona M. A. Abdel-Mottaleb et al. “A nanoparticle-based approach to improve the outcome of cancer active immunotherapy with lipopolysaccharides”. Drug Delivery, 2018; 25(1): 1414–1425; Nirmal D. Pugh, Hemlata Tamta. “The majority of in vitro macrophage activation exhibited by extracts of some immune enhancing botanicals is due to bacterial lipoproteins and lipopolysaccharides”. International Immunopharmacology, 2008 Jul; 8(7): 1023–1032).

In conclusion

Most of the plant-based or mushroom-based immunomodulators express both anti-inflammatory and anti-tumor effects. Natural immunomodulators from Japan enhance immune system reaction. That’s why they should be used under the supervision of the consulting doctor. For supporting badly decreased immune system in HIV, Hepatitis C virus or cancer treatment arabinoxylan would be the best choice. For stimulating immune response in treating numerous diseases one can choose agaricus-based immunomodulators. And as for prevention of diseases or mild support during the traditional therapy one can choose between Perilla extract, LPS or AHCC.