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John

Great product, original Japanese Lactis EL027826792JP
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Mike

Good effect. I shall order again. Original made-in-japan package as promised EG401137451JP
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May

Real Japanese laennec. Thank you! I shall order again. EJ377189782JP
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Bob

Great effect! Got my hair back in 3 months. EG401137588JP
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Nike

Lost 3 kilos since started to drink it last month. Great for fitness EG299855913JP
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Any

Bought it for my son. Good effect and great service. EG299855961JP
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Nya

Original touchi, fast delivery and good price. Thank you. EG401137156JP
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Sam

Good medicine. Think it really helps me to fight cancer. EL025661542JP
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John

3 times cheaper than in our country! And great effect for knees EJ365886698JP
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Mike

Great thing to support diet. Lost 4 kilos for 6 weeks. Shall order more EJ365886675JP
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Japanese immunomodulators: how to choose?

Japanese immunomodulators: how to choose?

Japanese immunomodulators: how to choose?

Japanese market can offer a lot of different immunomodulators. It’s easy to get lost in their number. Which of them are effective? And how to choose the immunomodulator from Japan that suits your particular needs? Let’s check it out.

Arabinoxylan

Arabinoxylan is a hemicellulose consisting of two pentose sugars, arabinose and xylose. It can be found in the cell walls of some plants. Studies show that this plant-based immunomodulator is effective in a conventional therapy in treating cancer (along with chemotherapy and radiotherapy), hepatitis C virus, human immunodeficiency virus (HIV) (Soo Liang Ooi, Debbie McMullen et al. “Evidence-Based Review of BioBran/MGN-3 Arabinoxylan Compound as a Complementary Therapy for Conventional Cancer Treatment” Integrative Cancer Therapies, 2018 Jun; 17(2): 165–178; Hosny Salama, Eman Medhat et al. “Arabinoxylan rice bran (Biobran) suppresses the viremia level in patients with chronic HCV infection: A randomized trial”. International Journal of Immunopathology and Pharmacology, 2016 Dec; 29(4): 647–653; Mamdooh Ghoneum and Magda Shaheen. “MRN-100, an Iron-based Compound, Possesses Anti-HIV Activity In Vitro”. Evidence-Based Complementary and Alternative Medicine, 2010 Dec; 7(4): 427–432). In our store you can order Japanese immunomodulators in different package and dosage:

Biobran immunomodulator

Agaricus mushrooms

Agaricus is a genus of mushrooms in Agaricomycetes class. Multiple studies show that extracts of some species of Agaricus mushrooms have immunomodulatory and immunostimulatory effects along with anti-tumor activities (Cynthia H. Val, Fátima Brant et al. “Effect of mushroom Agaricus blazei on immune response and development of experimental cerebral malaria”. Malaria Journal, 2015; 14: 311. https://malariajournal.biomedcentral.com/articles/10.1186/s12936-015-0832-y ; Fhernanda R. Smiderle, Andrea C. Ruthes et al. “Polysaccharides from Agaricus bisporus and Agaricus brasiliensis show similarities in their structures and their immunomodulatory effects on human monocytic THP-1 cells”. BMC Complementary and Alternative Medicine, 2011; 11: 58. https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-11-58 ; Yanqing Zhang, Guijie Ma et al. “The Immunostimulatory and Anti-tumor Activities of Polysaccharide from Agaricus bisporus (brown)”. Journal of Food and Nutrition Research, 2014, Vol. 2, No. 3, 122-126). That’s why Japanese immunomodulators from Agaricus fungi are effective in conventional therapy in treating cancer and in treating inflammations. In our store you can order two types of Agaricus-based immunomodulators from Japan: Agaricus with beta-glucans containing 1280 mg of agaricus extract in a daily dose or King Agaricus containing 1125 mg of agaricus extract and 1125 mg of agaricus mycelium extract in a daily dose.

Other plant-based immunomodulators

Amongst other plant-based immunomodulators from Japan we shall bring Perilla extract. Perilla extract has showed antioxidant, antimicrobial, anti-allergic, antidepressant, anti-inflammatory, anticancer, and neuroprotection effects in multiple studies (In Hwa Jeon, Hyeon Soo Kim et al. “Anti-Inflammatory and Antipruritic Effects of Luteolin from Perilla (P. frutescens L.) Leaves”. Molecules. 2014 Jun; 19(6): 6941–6951; Ragazinskiene O., Gailys V. et al. “Common perilla (Perilla frutescens (L.) Britton.) as a perspective immunomodulator”. Medicina (Kaunas). 2004; 40(3): 220-4).

One more effective immunomodulator, Active Hexose Correlated Compound (AHCC), is found in the Shiitake mushrooms. Researches have found that AHCC from Shiitake mushrooms increases immune reactions and can be used as an effective immunomodulator (Judith A. Smith, Lata Mathew et al. “From Bench to Bedside: Evaluation of AHCC Supplementation to Modulate the Host Immunity to Clear High-Risk Human Papillomavirus Infections”. Frontiers in Oncology, 2019; 9: 173; Peter Amwoga Ayeka. “Potential of Mushroom Compounds as Immunomodulators in Cancer Immunotherapy: A Review”. Evidence-Based Complementary and Alternative Medicine, 2018: 7271509).

AHCC immunomodulator medicine from Japan

Also we should name Lipopolysaccharides (LPS), also known as lipoglycans and endotoxins. This substance possesses monocyte/macrophage activation ability and is used for immunotherapy in cancer (Maryam A. Shetab Boushehri, Mona M. A. Abdel-Mottaleb et al. “A nanoparticle-based approach to improve the outcome of cancer active immunotherapy with lipopolysaccharides”. Drug Delivery, 2018; 25(1): 1414–1425; Nirmal D. Pugh, Hemlata Tamta. “The majority of in vitro macrophage activation exhibited by extracts of some immune enhancing botanicals is due to bacterial lipoproteins and lipopolysaccharides”. International Immunopharmacology, 2008 Jul; 8(7): 1023–1032).

In conclusion

Most of the plant-based or mushroom-based immunomodulators express both anti-inflammatory and anti-tumor effects. Natural immunomodulators from Japan enhance immune system reaction. That’s why they should be used under the supervision of the consulting doctor. For supporting badly decreased immune system in HIV, Hepatitis C virus or cancer treatment arabinoxylan would be the best choice. For stimulating immune response in treating numerous diseases one can choose agaricus-based immunomodulators. And as for prevention of diseases or mild support during the traditional therapy one can choose between Perilla extract, LPS or AHCC.

News

Shipping to USA, EU, Asia, Oceania and South America in April

Notification from 1st April 2021 - Regarding shipping in Pandemic and Japan Post Stop Act. Dear Customers!   WE CAN SHIP to USA, EU, UAE, Australia, New Zealand, Canada, Hong-Kong, China, Korea, Vietnam, Mexico and all other countries!   Japan Post imposed restrictions on shipping to most of other coutnries. Situation changes eevry day, you can find latest news here - https://www.post.japanpost.jp/int/information/index_en.html Please use search on page to find your country.   IF JAPAN POST DOES NOT SHIP OR SHIPS BY SURFACE MAIL ONLY WE CAN SHIP BY COURIER.   For shiping by Japan Post check this link with full list of countries https://www.post.japanpost.jp/int/information/overview_en.html For shipping by Сourier check table below or contact us as situation changes every day.   SEE TABLE BELOW. SEE COMMENTS BELOW TABLE IF YOU CAN NOT FIND YOUR COUNTRY -- CONTACT US! W CAN SHIP. Shipping type Economy Mail ** Express Service Methods: * SURFACE AIRMAIL Courier05 *** EMS  Argentina NO YES YES YES Armenia YES  YES YES NO Australia YES  YES YES NO Austria YES  YES YES YES Azerbaijan YES  YES YES NO Belarus YES  YES YES NO Belgium YES  YES YES YES Brazil YES NO YES NO Bulgaria YES  YES YES YES Canada YES  YES YES NO Chile NO YES YES YES China YES  YES YES YES Colombia NO YES YES YES Congo YES NO YES NO Costa Rica YES NO YES NO Croatia YES  YES YES YES Cyprus NO YES YES YES Czech YES  YES YES YES Denmark YES  YES YES YES Ecuador NO NO YES NO Egypt YES YES YES NO Estonia YES  YES YES YES Finland YES  YES YES YES France YES  YES YES YES Georgia YES NO YES NO Germany YES  YES YES YES Great Britain YES  YES YES YES Greece YES  NO YES NO Hungary YES  YES YES YES India YES  NO YES NO Indonesia YES  YES YES YES Iran / Iraq NO YES  NO YES Ireland YES YES YES YES Israel YES NO YES NO Italy YES  YES YES YES Kazakhstan YES  YES NO NO Kenya NO YES YES YES Laos YES NO YES NO Latvia YES  YES YES YES Liechtenstein YES  YES YES YES Lithuania YES  YES YES YES Luxemurbg YES  YES YES YES Malaysia YES  NO YES NO Mexico YES  YES YES YES Moldova YES NO YES NO Mongolia NO NO YES NO New Zealand YES  YES YES YES Norway YES  YES YES YES Pakistan NO YES YES YES Panama NO NO YES NO Peru YES NO YES NO Poland YES  YES YES YES Portugal YES  YES YES YES Romania YES  NO YES NO Russia YES NO NO (ASK US) NO Saudi Arabia YES NO YES NO Serbia YES  YES YES NO Slovakia YES  YES YES NO Spain YES  YES YES YES Sri Lanka YES  YES YES YES Sweden YES  YES YES YES Switzerland YES  YES YES YES Tajikistan YES NO YES NO Turkey YES  YES YES YES UAE (Dubai) YES  NO YES NO Ukraine YES YES NO YES USA YES  YES* YES NO Uzbekistan YES NO YES NO Vietnam YES  YES YES YES           * We select appropriate available method. If you need specific method contact us. ** Economy mail is shipped by Air if airmail is available, if not we ship by Surface mail. There are restrictions applied by Japan Post. *** Courier-05, shipping for parcels with tablets up to 5 boxes (most cases), vials 10-20 pcs drops up to 0,5 kg in weight. Can ship to specific regions/cities, please check before order. IF YOU DO NOT SEE COUNTRY ON LIST, CONTACT US!   USA: - EXPRESS SERVICE. We ship by express, Delivery takes 8-12 days.  - AIRMAIL MAIL. If you prefer economy mail, we ship by surface mail, takes 2-4 weeks, no tracking, only local number in Japan, Rate starts at 29 usd, free shipping for orders above 400 usd and 2 kg. If you can wait use this method.   EU - EUROPE We ship as usual to all countries besides Greece, Romania, Moldova and Russia.  For Romania, Greece and Moldova: We ship using express service to all other countries in EU at the moment. Or by surface mail.   ASIA - SINGAPORE, HONG KOG, KOREA, TAIWAN, THAILAND, VIETNAM, MALAYSIA, PHILIPPINES. We ship as usual (with possible delays) to these countries   SHIPPING TO CHINA. We ship as usual by EMS or Airmail.    SHIPPING TO INDIA. - WE CAN SHIP BY COURIER. We can ship by express method almost everything. Delivery takes 8-14 days. USE EXPRESS METHOD. - WE SHIP BY SURFACE MAIL. This takes 6-8 weeks or more, we offer tracking, Rate starts at 19 usd, free shipping for orders above 400 usd. If you can wait use this method. We can only ship vials and glass using surface mail.   OCEANIA - AUSTRALIA. NEW ZEALAND To Australia: - EXPRESS SERVICE. We ship by express, Delivery takes 8-12 days.  - AIRMAIL MAIL. If you prefer economy mail, we ship by surface mail, takes 2-4 weeks, no tracking, only local number in Japan, Rate starts at 29 usd, free shipping for orders above 400 usd and 2 kg. If you can wait use this method. TO NEW ZEALAND - WE SHIP AS USUAL    BRAZIL - WE CAN SHIP BY COURIER. We can ship by express method almost everything. Delivery takes 8-14 days. USE EXPRESS METHOD. - WE SHIP BY SURFACE MAIL. This takes 10-15 weeks or more, we offer tracking, Rate starts at 19 usd, free shipping for orders above 400 usd. If you can wait use this method. We can only ship vials and glass using surface mail.   CANADA - EXPRESS SERVICE. We ship by express, Delivery takes 8-12 days.  - AIRMAIL MAIL. If you prefer economy mail, we ship by surface mail, takes 2-4 weeks, no tracking, only local number in Japan, Rate starts at 29 usd, free shipping for orders above 400 usd and 2 kg. If you can wait use this method.   UKRAINE, KAZAKHSTAN. RUSSIA. - WE CAN SHIP TO KAZAKHSTAN AND UKRANE as usual by  AIRMAIL WITH POSSIBLE DELAYS. EMS and courier is available for Ukraine.  - Only surface mail is allowed for Russia due to strict customs control for all other methods.
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Reviews

John

Great product, original Japanese Lactis EL027826792JP
more ▶

Reviews

Mike

Good effect. I shall order again. Original made-in-japan package as promised EG401137451JP
more ▶

Reviews

May

Real Japanese laennec. Thank you! I shall order again. EJ377189782JP
more ▶

Reviews

Bob

Great effect! Got my hair back in 3 months. EG401137588JP
more ▶

Reviews

Nike

Lost 3 kilos since started to drink it last month. Great for fitness EG299855913JP
more ▶

Reviews

Any

Bought it for my son. Good effect and great service. EG299855961JP
more ▶

Reviews

Nya

Original touchi, fast delivery and good price. Thank you. EG401137156JP
more ▶

Reviews

Sam

Good medicine. Think it really helps me to fight cancer. EL025661542JP
more ▶

Reviews

John

3 times cheaper than in our country! And great effect for knees EJ365886698JP
more ▶

Reviews

Mike

Great thing to support diet. Lost 4 kilos for 6 weeks. Shall order more EJ365886675JP
more ▶