Progynon Depot: effects and application area.

Is Progynon Depot effective?

The active substance of Estradiol Valerate is sold worldwide under several names and trademarks across the globe. In Japan, it is known as Progynon Depot. This drug is widely used not only in Japan, but throughout the world. The scope of its application is quite wide - the following recognized areas of use for Proginon Depot can be enlisted:

• hormone therapy
• with a low level of estrogen,
• for the treatment of menopause symptoms,
• as hormonal contraception,
• for the treatment of prostate cancer (men).
• in the treatment of breast cancer (women).

Progynon Depot is administered intramuscularly, by applying once a week or once every few weeks, depending on the prescription of physician. Clinics started to use Estradiol Valerate actively since 1954. Starting from this year Progynon has gained wide popularity in the United States, Canada, Europe, Japan and many other countries over the world.

Estradiol is a naturally synthesized form of estrogen, because it is considered a natural active component and compared to numerous analogues, it causes less harm, with sufficiently significant positive therapeutic effects.

Estradiol Valerate sold in Japan under brand name Progynon Depot is available in different countries in the form of injections and in the form of tablets. However, injections are incomparably more effective than pills. For example. 4 mg. of medicine, administered intramuscularly, produces medical effect equivalent to the use of 2 mg of tablet medicine taken during three weeks (Düsterberg B, Nishino Y (December 1982). "Pharmacokinetic and pharmacological features of estradiol valerate". Maturitas. 4 (4): 315–24 ). This is one of those cases where injections are several times more effective. After intramuscular injection, the maximum concentration of Progynon in blood is maintained for three days at the level of 390 picograms per milliliter. After 3 days it drops three times, and it continues to maintain this level for another 9-10 days (Climacteric in Perspective: Menopause, held at Lake Buena Vista, Florida, October 28 – November 2, 1984. Springer Science & Business Media (pp. 397, 399).

At this moment, Progynon Depot is one of the most effective methods applied for hormonal therapy, as well as for therapeutic methods mentioned at the beginning of this article. Pay attention to possible contraindications and precautions before using Estradiol Valerate. If necessary, consult with your physician.

You can also check the following related article about menopause treatment:

Clinical trials of Melsmon: effects and contraindications